ID D2VVK7_NAEGR Unreviewed; 361 AA.
AC D2VVK7;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39052.1};
GN ORFNames=NAEGRDRAFT_73053 {ECO:0000313|EMBL:EFC39052.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39052.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39052.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738902; EFC39052.1; -; Genomic_DNA.
DR RefSeq; XP_002671796.1; XM_002671750.1.
DR AlphaFoldDB; D2VVK7; -.
DR STRING; 5762.D2VVK7; -.
DR EnsemblProtists; EFC39052; EFC39052; NAEGRDRAFT_73053.
DR GeneID; 8858164; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_73053; -.
DR eggNOG; KOG1198; Eukaryota.
DR InParanoid; D2VVK7; -.
DR OMA; CDIRGVF; -.
DR OrthoDB; 102245at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08241; QOR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43677:SF4; QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 21..348
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 361 AA; 39442 MW; D8C65B407EFD5CFC CRC64;
MSHQQTPHYQ IVCKELVFPP TSESVQVVQA PKNLLSEPLA KNHVRIKILY GCLNYADALQ
CGGKYQEKMN APFIPGKELA GIVCDVNGKG DRFKVGDCVI MLAEKDGWQS FIDLPLLYPA
IIKVPKSVDL KKAASLLVAY STSHVALTHP RHGALTQHDG KSKRSTVLVL GASGGVGLAA
VQIAKSLGAI VIAACSSDEK CKICTEKGQA DFVVNYSSNK KDWFKQVLEF TKGKGCDIIY
DPVGGDLALQ SLKCIAWGGS LIVIGFASSI QQIPANILLV KNVRATGCYW GSYMKHEPQV
IQQSMATLFE MLVKKQIDPY VSECYPIESV AKAMNDMLER KTVGRVLLSF PQQENIRPSK
L
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