ID D2W3W6_NAEGR Unreviewed; 2426 AA.
AC D2W3W6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36266.1};
GN ORFNames=NAEGRDRAFT_60042 {ECO:0000313|EMBL:EFC36266.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC36266.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC36266.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG738934; EFC36266.1; -; Genomic_DNA.
DR RefSeq; XP_002669010.1; XM_002668964.1.
DR EnsemblProtists; EFC36266; EFC36266; NAEGRDRAFT_60042.
DR GeneID; 8860936; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_60042; -.
DR eggNOG; KOG1023; Eukaryota.
DR InParanoid; D2W3W6; -.
DR OrthoDB; 5482760at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14279; CUE; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 942..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1207..1273
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1364..1492
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 22..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2085..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2389..2426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2090..2117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2408..2426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2426 AA; 275329 MW; 7C5CDF83D9C3A29D CRC64;
MSSSNSCNED SAAVLIIPTH TNHHLNVTTS PKSPTPSSNV PFLAQNSKKQ KSQASVRSLL
LEKRKSTSRI TPLDSIQSHS KPRLNNSNQN IQSPHKLVST QSTASIRTAR SSRSIRSIQR
PSTNSSKLKE IKSKSTDFWD EDAKDETPHP EDEDDENTTV MNEYIDKYLM FIQAVKLENP
LHRFISITLH IFIMIQSLVL GCSLDFGWGE YGKYIMNVLV IPRTFGFQYL PYEAYIGLAA
ALLLLESIAI AIIYMTYRSL VYGTSYWKRI RTAGRIAFTS ITLCSMPVTF ALIHAFFDCD
YEKTVTLSGA YDATYVLRRS TNSVYGGIGF ARLGVGISAL VSTLVNKNDD WDLGLGLTFA
PIVLGIVGFV IGFIVTDIYT RRIMTKGQQI ASVVTSSQST HELNFNHSNL PALANFIKFA
LKGTEEQQDI IFDFVRILFR TTDSISCNCL INMALYSKDI CKPPNYFQAS TFLKKAEQRK
PNFRQQFAIY MRMAELEKSL AINMKIKGTV GETVIERLNL RMKKLRIMII EFWKLVSSKS
NVDHILQKIE SLSYELDVAF QNLILDHEED ETIQQLYKHY QREFNFMAMG NEDEEEEKPI
KESEKPPMQF LALSPTKNNL FATDDLMLDN FDSISMMGEE EEENFETVLD KQQEIFTNAI
SKPDENEKLF YFLNTSGGFQ LLFILMVLII GLSLLFKLTS LDLFDSVSVL TALPFSALIN
INNLNGQVGP LNTTSIWSIP TFRSKINTLG SSKAVKLENL NELFSTQYDD TVVEYYNAED
KLILVDDESG SWKYTSTNWI AKRNKMLLLT LVDLINQTKS SDKISLDNSQ FTFLGNNVER
MSNGFAQFFE DIYKYLYSDL NSTTNDFIIV VVFIFFSFLV YSIVHSLFLL RFIYNRKLIL
RLFHQVPQEE SRFLITTMEK VVGEEQDVKS STKSLFTSVT KLIFLDIFSI LVTCVALSMI
IADVFTDFQA HTYGVVKLRE MSYAMSYEQQ IRYDIFQMVL HLDNQTFREE RSKLLLDHIT
SFDTHWTATR YGSSVDGYLS LSGVNSNLDN LLGKTSSNCS TFSCNSMDDK VGFFRAQAVK
LNEILRVYNG TVSDLNKIPE FLYLTAYDLY GTFGSLNEIL YYAYFNSQPY FTIIGTVVGI
PLLLLCYMLN FMTMKNVRNE NYVLRKMLNY LHWEVLDSND DLRNYIFHHI LKTDPKEKSK
RKVPKERAIL EAALTSAIVC SANGTIDIFN NASEKLFGFR SDQMIGFPLV KLFDKSSEAS
LQPIITQMSM ASSGYSETLE LVGVRKNLAT VSVEMRICVS VTDSRNVITC FIRDLTEIKM
QVKELAEQKK KSEALLMNIM PYSVAKRLQE GGENLIADKF DHVTCIFSDI VGLLDLGLSA
TDLVQNLNDL VMQFDEACVR FNLEKIKTIQ SKYFCTGGLK ANEMKDEEHE LRVFEFALNL
FEIFNDFQLR NEHRNWNIGL RAGINAGPLV AGVCGVLKYA YDIWGDAVNA ASLEVATESV
AFVSNAPSGK LIMHGTLYKP IISGSETTVQ RGAVVLVHGS GASNRNESAM NYAFLNTMGF
PKKDPNCGLT FMNFQVFYEL GMELAKSGLV VLTYDKRGHC SGHEECKLCT VNQLTHHFEN
CWYGGPSDAP QQFDYNLVTL DDFAIDAVSG LEYLSTRPDV NPSKLGILGH SEGVNVVLKS
FNLFNSESNV KMGKQVINVF LMNGLVFNYG QFLVKQNLRM VTNWNILKEA CEKEDPTSQL
IPIANSNMDI SNKTAVALAN FFPLFEKGSY PIDWAYNIGG YVSGRFIQSA FNYTSIEFTK
LHLLKSATMP FVCALNSPTD ANVHPEDYKN LIDVLSQRDA RLTFSQVYPN LTHFDSPSDL
STTVESHPEN PLLEKYVKTL DSFTVSDLEE IEQLLGKVSS AKLKNLLQRD LTLARSKLST
RLLNESVERE NEKRGHFVKK KTILVEREIE IIEEDEEGYI QQHVKGYKEK VRSLKQLLPD
KKTKEIRDAL IRCKGREEAA MEGLLTGELP RRPDIPKIKT KKIIKEAKEV IETESLSTNS
ENPPIQFFED VTLPKYENNV NVLSDRIKRM KEMIDMEKKE TDRLTKQVES FKSKSSSSSL
GDWIGKNETG SSSNDGTLTE EEEYKKNRMY LPGEYETMER DEPRTFTFKP ERTFSNEVSH
IHFRVAESEF YRLLTTKTQF RITEVKYVVT PGLVKQFEAS RHNLAYDLNT KYPEVKPILT
FMDISDYSDD NIDWICKNGV RNNSGKPYVF TNLAAQANAV IAKNTKIMLF LVLPGRSAVR
DLNKLQNADI SSLGANHSLR TSDSMNHAVF NNELILPYYV VSYSNSQTTY NPQTGTVQGV
VRLDEEWKHI EANAQADKFM NDVKEFYQKA LIQGSKERVL DPTTFVNDVM EDESTPGSGL
SGGDQFDMDT PTPGTASSFK FEDDTF
//