ID D2W4D0_NAEGR Unreviewed; 545 AA.
AC D2W4D0;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36066.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_54589 {ECO:0000313|EMBL:EFC36066.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC36066.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC36066.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG738949; EFC36066.1; -; Genomic_DNA.
DR RefSeq; XP_002668810.1; XM_002668764.1.
DR AlphaFoldDB; D2W4D0; -.
DR EnsemblProtists; EFC36066; EFC36066; NAEGRDRAFT_54589.
DR GeneID; 8859785; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_54589; -.
DR InParanoid; D2W4D0; -.
DR OrthoDB; 465497at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR PANTHER; PTHR13833; -; 1.
DR PANTHER; PTHR13833:SF71; NHL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07974; EGF_2; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 508..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 287..296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFC36066.1"
SQ SEQUENCE 545 AA; 58786 MW; AD81CC02A7606074 CRC64;
ELYFSDYLHD RVRKITSSGL VETVAGGIGD KGLAVNAKIR GVSSILLVDN DLYISDAFNY
RIRKISLSTG IIDSIVGAYA SIYNGDNWAN QTNINYVWDM RIQNGELVFA DMNNNLIRKT
SLSGKGKVTT IAGMGANNAS IIIDNVKATS AYLKNPGSVA FLPTGDMIIA ETEGHIIRKV
DLNGNISLIA GSFFQPGFNG DLSDSKNSLL YQPTGLSILQ DGRIIFSDFG NNRVRMLTPY
CKDEKYYLTQ SSQGIVCNIT SCYGLAYNDA KVCSGNGICS SLNNCSCSSG YSGNDCSTAD
ICSVLSSSYV CTTTSLNTTE TQVTTVQNVT QLDSKTIEFS STSTVTVSLP STISQYLTSV
DSTLKNDTVT VVSSVSSASK VTETSEVISP VISIVLVKSS SNQKISVQNL EEPISLYFNK
VNMTVSNIET LNVTCMYYDE SEKVWKSDGV ESEITEIILH NLADGNVTLT ISLTCKTFHL
TSFGIIDQNY KKATTNSNTD DSTILTDYTV LIGAIVGGVG GCCVIATIIT LIIVVIIFVR
RRGKK
//