ID D2W6V8_NAEGR Unreviewed; 340 AA.
AC D2W6V8;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC35194.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_77151 {ECO:0000313|EMBL:EFC35194.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC35194.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC35194.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG739604; EFC35194.1; -; Genomic_DNA.
DR RefSeq; XP_002667938.1; XM_002667892.1.
DR AlphaFoldDB; D2W6V8; -.
DR EnsemblProtists; EFC35194; EFC35194; NAEGRDRAFT_77151.
DR GeneID; 8847774; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_77151; -.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; D2W6V8; -.
DR OrthoDB; 5491728at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR001258; NHL_repeat.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01436; NHL; 1.
DR SMART; SM00181; EGF; 3.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 172..205
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 244..283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 195..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 273..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFC35194.1"
FT NON_TER 340
FT /evidence="ECO:0000313|EMBL:EFC35194.1"
SQ SEQUENCE 340 AA; 34848 MW; 52B2FFF3186DD14D CRC64;
GTIVTFAGNG QSGHIGDGGQ AISAALSQAY GVRVVNDEVY ISDSNNFKVR KIDVSGVITT
IAGTGAGPFN GDNILATAAN LNHPTDVAFL SNGEMLIADT DNNRVRMVLT NGTIVSIAGN
GTASFSDGRI ATSRGLSLPT GILVVSDVEI YIADAKNGRI RLLSTKQTVC YDVDASENSA
CNGNGLCFDT DTCVCQQGWS GANCNITSCS GVSSNDNSVC SGHGSCVNTE TCVCKQGWYS
ANCNVTSCFG VASNDSSVCG GHGSCLSLDQ CSCTGLWTGS NCNVTSGNSN NEAATYIYGI
STFAGGNGEF VDPQKIARLS NGDLIVSDAT GHAIKKISKI
//
