ID D2XVG0_MELCN Unreviewed; 557 AA.
AC D2XVG0;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE Flags: Fragment;
GN Name=Pgi {ECO:0000313|EMBL:ADB11192.1};
OS Melitaea cinxia (Glanville fritillary) (Papilio cinxia).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Nymphalinae; Melitaea.
OX NCBI_TaxID=113334 {ECO:0000313|EMBL:ADB11192.1};
RN [1] {ECO:0000313|EMBL:ADB11192.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4BH {ECO:0000313|EMBL:ADB11192.1};
RX PubMed=19793833; DOI=10.1093/molbev/msp227;
RA Wheat C.W., Haag C.R., Marden J.H., Hanski I., Frilander M.J.;
RT "Nucleotide polymorphism at a gene (Pgi) under balancing selection in a
RT butterfly metapopulation.";
RL Mol. Biol. Evol. 0:0-0(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|RuleBase:RU000612}.
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DR EMBL; GU263944; ADB11192.1; -; mRNA.
DR AlphaFoldDB; D2XVG0; -.
DR UniPathway; UPA00109; UER00181.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 2: Evidence at transcript level;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
FT NON_TER 557
FT /evidence="ECO:0000313|EMBL:ADB11192.1"
SQ SEQUENCE 557 AA; 61756 MW; D4176D7A4FDFB80C CRC64;
MEPKVNLKQD PAYKKLQEFY DVNGGKINIL QLFQQDPERF NKFSLRIPTP NDGDILLDYS
KNRVDAAALS LLLELAKSRG VEQARDAMFS GQKINFTEDR AVLHIALRNR KNRPILVNGK
DVTPDVNAVL AHMKEFSEQV ISGKWKGYTG KAITDVINIG IGGSDLGPLM VTEALKPYAN
HLKVHFVSNI DGTHLAEVLK KLNPETALFI IASKTFTTQE TITNATSAKN WFLDVAKDPS
SVSKHFVALS TNGEKVSAFG IDPKNMFGFW DWVGGRYSLW SAIGLSISLY VGFENFEKLL
EGASFMDNHF TTAPLEKNAP VILALLGVWY SNFYGAETHA LLPYDQYLHR FAAYFQQGDM
ESNGKYVTRG GDEVRYSTGP IVWGEPGTNG QHAFYQLIHQ GTRLIPCDFI APAQTHNPIS
GGVHHKILLA NFLAQTEALM KGKTAEEAKA ELEKSGMAPE AIAKILPHKV FKGNRPTNSI
VVKKVTPFTL GALIAMYEHK IFTQGVIWDI NSFDQWGVEL GKQLAKAIEP ELQDSKPVAS
HDASTNGLIN FLKQNFA
//
