ID D2Z009_PLEAT Unreviewed; 287 AA.
AC D2Z009;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Myeloid differentiation primary response protein MyD88 {ECO:0000256|PIRNR:PIRNR037756};
GN Name=MyD88 {ECO:0000313|EMBL:BAI68385.1};
OS Plecoglossus altivelis altivelis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes;
OC Plecoglossus.
OX NCBI_TaxID=281464 {ECO:0000313|EMBL:BAI68385.1};
RN [1] {ECO:0000313|EMBL:BAI68385.1}
RP NUCLEOTIDE SEQUENCE.
RA Suzuki K., Izumi S., Tanaka H., Katagiri T.;
RT "Molecular cloning and characterization analysis of TLR5, MyD88 and TRAF6
RT cDNA and its gene in ayu, Plecoglossus altivelis altivelis.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC receptor signaling pathway in the innate immune response.
CC {ECO:0000256|PIRNR:PIRNR037756}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037756}.
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DR EMBL; AB516398; BAI68385.1; -; mRNA.
DR EMBL; AB516399; BAI68386.1; -; Genomic_DNA.
DR AlphaFoldDB; D2Z009; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; MYD88; 1.
DR PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037756; MyD88; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037756};
KW Immunity {ECO:0000256|PIRNR:PIRNR037756};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037756}.
FT DOMAIN 26..104
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 150..284
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 287 AA; 32997 MW; A2D0F9CEA7ED2BCB CRC64;
MSSVTALSFD ISNIPLVALN VNVRKKLGLF LNPRNTVAAD WMSIAEIMGF SYLEITNYEN
CQNPTRKILE DWQARCPDAK VGKLLSILEE ADRKDVVEDL RELIEEDCRK YLSWQKEPPV
QVPEVDSCVP RTPERSRITL EDDPDGGMPE LFDAFICYCQ SDFTFVNEMI QQLEQTEHKL
KLCVFDRDVL PGSCVWTITS ELIEKRCKRM VVVISDNYLD SDACDFQTKF ALSLCPGARS
KRLIPVVYKS MKKPFPSILR FLTVCDYTRP CTQAWFWIRL AKALSLP
//
