ID   D2ZMJ9_METSM            Unreviewed;       448 AA.
AC   D2ZMJ9;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Uracil permease {ECO:0000313|EMBL:EFC94077.1};
GN   Name=pyrP {ECO:0000313|EMBL:EFC94077.1};
GN   ORFNames=METSMIF1_02048 {ECO:0000313|EMBL:EFC94077.1};
OS   Methanobrevibacter smithii DSM 2374.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=521002 {ECO:0000313|EMBL:EFC94077.1, ECO:0000313|Proteomes:UP000004028};
RN   [1] {ECO:0000313|EMBL:EFC94077.1, ECO:0000313|Proteomes:UP000004028}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2374 {ECO:0000313|EMBL:EFC94077.1,
RC   ECO:0000313|Proteomes:UP000004028};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFC94077.1}.
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DR   EMBL; ABYV02000002; EFC94077.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2ZMJ9; -.
DR   PATRIC; fig|521002.11.peg.46; -.
DR   HOGENOM; CLU_017959_1_2_2; -.
DR   Proteomes; UP000004028; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   448 AA;  46977 MW;  529D3820E75F3887 CRC64;
     MLSLNNYFVK KEFFEVKGDK MSENSNMLLG VKDKPPAVNW ILLAIQHVCA MFGATILVPI
     VVNTTVGSDV LSIPVALVTS GIGTLIYIAC TRGRSPVYLG SSFAFIAPMV AGYAIAGKAS
     VFTAIMCVGI VYAIISTIIR VVGKEWINKI LPPVVVGPMI MIIGLSLAPT AIEEIGLNAS
     SVPITSLIIA FVAFLSTAIL AVRGKGILRV IPFLIGIIIG YIVAALLGVV DFSGVASAHI
     IEIPKFYIPF VDYNLNFGAI LTIVPIALVT MVEHVGDHKV LSEIIGRDLI QDPGLDRTLL
     GDGIATFIAA LLGGPANTTY GENTSVVGMT RVASVYVIGL AAIIAIIFAF SGHLTALLTA
     IPSPVLGGIS ILLYGFICVN GLKILIHNHV DFTNTKNVVV AATMLVLGLG GATLSIAYGN
     LSLAISGMSL AAIIGIILNL CIPEEKHE
//