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Database: UniProt
Entry: D3CTB1_9ACTN
LinkDB: D3CTB1_9ACTN
Original site: D3CTB1_9ACTN 
ID   D3CTB1_9ACTN            Unreviewed;       515 AA.
AC   D3CTB1;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-SEP-2017, entry version 48.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=FrEUN1fDRAFT_0778 {ECO:0000313|EMBL:EFC86167.1};
OS   Frankia sp. EUN1f.
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=102897 {ECO:0000313|EMBL:EFC86167.1, ECO:0000313|Proteomes:UP000004777};
RN   [1] {ECO:0000313|EMBL:EFC86167.1, ECO:0000313|Proteomes:UP000004777}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EUN1f {ECO:0000313|EMBL:EFC86167.1,
RC   ECO:0000313|Proteomes:UP000004777};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Tice H., Bruce D., Goodwin L.,
RA   Pitluck S., Larimer F., Land M.L., Hauser L., Beauchemin N., Sen A.,
RA   Fernandez M., Tisa L.;
RT   "The draft genome of Frankia sp. EUN1f.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFC86167.1}.
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DR   EMBL; ADGX01000008; EFC86167.1; -; Genomic_DNA.
DR   RefSeq; WP_006538618.1; NZ_ADGX01000008.1.
DR   EnsemblBacteria; EFC86167; EFC86167; FrEUN1fDRAFT_0778.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004777; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004777};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004777}.
FT   DOMAIN      206    334       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      418    487       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     214    221       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   515 AA;  56840 MW;  23DB979D89ADE732 CRC64;
     MTDLSADSVA GLPSRGATPP SDPDLSAVWE QAVAGVADGA LSAQQRAWLR LTRPLGLVQD
     TALLAAPNEF TKDLLDSRLR PFLSTALSRA YGREIRVAVT VEHTPDPEPM TGPLIRPATT
     ADLTQHLMGG GSGTALNEGA ESVDGVRVDG PPPGRVSPGL GRDPSPRPSE PARLNPRYLF
     ETFVIGDSNR FPHAAAVAVA EAPAKAYNPL FIYGDSGLGK THLLHAIGHY TVKLYPESRI
     KYVSMEEFTN DFIASIRDDR QLAFQRRYRD IDVLLVDDIQ FLENKERTQE EFFHTFNVLH
     DTEKQIVISS DRSPKQLAAL EDRLRSRFEW GLITDVTPPD LETRIAILSK KAATERLPVP
     PDVLEYIATH IERNIRELEG ALIRVAAFAS LNKSHVDRTL AEIVLRDLIP DAANPEITAA
     AIMNATAAYF GISMDDLCGT SRSRVLVTAR QIAMYLCREL TDLSLPKIGQ HFGGRDHTTV
     MHADRKIRGL MAERRAIYNQ VTELTNRIRA QARHA
//
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