ID D3CX83_9ACTN Unreviewed; 397 AA.
AC D3CX83;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EFC84702.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:EFC84702.1};
GN ORFNames=FrEUN1fDRAFT_2153 {ECO:0000313|EMBL:EFC84702.1};
OS Parafrankia sp. EUN1f.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC Parafrankia.
OX NCBI_TaxID=102897 {ECO:0000313|EMBL:EFC84702.1, ECO:0000313|Proteomes:UP000004777};
RN [1] {ECO:0000313|EMBL:EFC84702.1, ECO:0000313|Proteomes:UP000004777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EUN1f {ECO:0000313|EMBL:EFC84702.1,
RC ECO:0000313|Proteomes:UP000004777};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Tice H., Bruce D., Goodwin L.,
RA Pitluck S., Larimer F., Land M.L., Hauser L., Beauchemin N., Sen A.,
RA Fernandez M., Tisa L.;
RT "The draft genome of Frankia sp. EUN1f.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFC84702.1}.
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DR EMBL; ADGX01000026; EFC84702.1; -; Genomic_DNA.
DR RefSeq; WP_006539991.1; NZ_ADGX01000026.1.
DR AlphaFoldDB; D3CX83; -.
DR Proteomes; UP000004777; Unassembled WGS sequence.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:EFC84702.1};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EFC84702.1}.
FT DOMAIN 5..266
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 275..396
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 353
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 383
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 397 AA; 41568 MW; 0DCF00F68DA3FA5A CRC64;
MRDAVIVEAV RTPIGRGRAT GSLAPVHPID LLAHSISAVV ERAGIDPTHI DDVIAGCVTQ
TGEQSANIAR WAGLAAGLPE SVPATTVDRQ CGSSQQAVHF AAQGVIAGAY DMVVACGVES
MGRVPMGSAT QPGDSRGVRI NERYPAGLVP QGISAELIGA RRGTPRAQLD EFALASHQRA
FAATREGLLT PEIAPVKVTQ ADGSVVEVSA DEGIRPSTSM EALAGLRPAY YDEAAAARFP
EIGWNVTAGN ASQISDGSAA LLITTSERAR ELGLRPRARL HSFVVVGDDP FLMLRGVIPA
TRRVLERSGL RLDDIDLFEV NEAFATVVLD WRAEIGAPAE RVNTRGGAIA LGHPLGASGA
RIMTTLVHAL EQTGGRYGLQ TMCEAGGLAN ATILERL
//
