ID D3DFH7_HYDTT Unreviewed; 736 AA.
AC D3DFH7;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN Name=mrcA {ECO:0000313|EMBL:BAI68579.1};
GN OrderedLocusNames=HTH_0112 {ECO:0000313|EMBL:BAI68579.1};
OS Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae;
OC Hydrogenobacter.
OX NCBI_TaxID=608538 {ECO:0000313|EMBL:BAI68579.1, ECO:0000313|Proteomes:UP000002574};
RN [1] {ECO:0000313|EMBL:BAI68579.1, ECO:0000313|Proteomes:UP000002574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6534 / IAM 12695 / TK-6 [Tokyo]
RC {ECO:0000313|Proteomes:UP000002574};
RX PubMed=20348262; DOI=10.1128/JB.00158-10;
RA Arai H., Kanbe H., Ishii M., Igarashi Y.;
RT "Complete genome sequence of the thermophilic, obligately
RT chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter
RT thermophilus TK-6.";
RL J. Bacteriol. 192:2651-2652(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
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DR EMBL; AP011112; BAI68579.1; -; Genomic_DNA.
DR RefSeq; WP_012962762.1; NC_017161.1.
DR AlphaFoldDB; D3DFH7; -.
DR STRING; 608538.HTH_0112; -.
DR CAZy; GT51; Glycosyltransferase Family 51.
DR KEGG; hth:HTH_0112; -.
DR PATRIC; fig|608538.5.peg.114; -.
DR eggNOG; COG5009; Bacteria.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000002574; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002574}.
FT DOMAIN 55..227
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 396..657
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 736 AA; 82953 MW; C2940132B6CD7EB8 CRC64;
MVRRVLVVFL GAVSLIFAFV LFALFILSTD LPSVEKLKDW RPPEATLIYD YKGRVFGDVA
VQRRYYVPLK DIPLYVRQAF IAAEDRNFYS HFGIDPIAVL RALIANIRER EITQGASTIT
QQLARNLFLT PERSFKRKVK EMLLAIKIER AFSKDKILEM YLNYIYLGQG AYGVEAASRI
YFGKHVKDLT LDEAALLAGL PKAPTKYNPF RNPEKVKERR NYVLQRMYED GYITQDELKR
YSSVPIRVKL ENRYYGMDYF LDYVKDYLVE KYGEAILAGG YKVYTTIDRD LQMHAREAVK
RGVMRVAKAN GIPFLPDDPY EVQKKYEEQQ VELKPWRIYI GKVLDVGSQE LKVAVKDYQF
TVPRNQLPVE KGDYVLVRFV KRGKDISAEV LPDLEGALVA LDAKTGAIRA MVGGYSYLRS
PYNRAVYAKR QPGSAIKPII YLAALMKGYT QASTIDATPK SFFDPSKGKE WTPKNYEGAE
YGVVTLRTAI AKSINTATVN LLSEIGFDMP MQVGKSLGID LKPYYSMALG SIEVTPLELT
SAYQAFADLG IRCEPYFIQR IVAPDGKVIE ENNPKCEQVL PPQEVRVLVD MLRAVVLEGT
AASASSFGRI VAGKTGTTND YMDAWFVGFS PYIVAGVWVG YDIKKSMGKG MAGARVALPI
WLDFMSVAAF MYPNEDFPVP DGVVVVNCPT PMYFVDGTQG ICSGEQKQDE TNELKGIVDP
NILKKLEEEP KVKEIP
//
