ID   D3E0M8_METRM            Unreviewed;       372 AA.
AC   D3E0M8;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=ORC1-type DNA replication protein {ECO:0000256|HAMAP-Rule:MF_01407};
GN   OrderedLocusNames=mru_0423 {ECO:0000313|EMBL:ADC46274.1};
OS   Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 /
OS   OCM 146 / M1) (Methanobacterium ruminantium).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=634498 {ECO:0000313|EMBL:ADC46274.1, ECO:0000313|Proteomes:UP000008680};
RN   [1] {ECO:0000313|EMBL:ADC46274.1, ECO:0000313|Proteomes:UP000008680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1
RC   {ECO:0000313|Proteomes:UP000008680};
RX   PubMed=20126622; DOI=10.1371/journal.pone.0008926;
RA   Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J.,
RA   Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C.,
RA   Janssen P.H., Dey D., Attwood G.T.;
RT   "The genome sequence of the rumen methanogen Methanobrevibacter ruminantium
RT   reveals new possibilities for controlling ruminant methane emissions.";
RL   PLoS ONE 5:E8926-E8926(2010).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000256|HAMAP-Rule:MF_01407}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000256|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; CP001719; ADC46274.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3E0M8; -.
DR   STRING; 634498.mru_0423; -.
DR   KEGG; mru:mru_0423; -.
DR   PATRIC; fig|634498.28.peg.425; -.
DR   eggNOG; arCOG00467; Archaea.
DR   HOGENOM; CLU_025112_3_0_2; -.
DR   Proteomes; UP000008680; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd18139; HLD_clamp_RarA; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR   PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR10763:SF32; ORC1-TYPE DNA REPLICATION PROTEIN 2; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_01407};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01407};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_01407}; Reference proteome {ECO:0000313|Proteomes:UP000008680}.
FT   DOMAIN          299..371
FT                   /note="Cdc6 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01074"
FT   BINDING         63..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT   BINDING         205
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT   BINDING         217
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   372 AA;  42073 MW;  02D01230AE71E10D CRC64;
     MAIEDILMFD ETIFNDINAF NPDYMPPNYN FRDSQMEGMA MAIRPAIRGG RPTNSVILGS
     CATGKTTAIK KVFELVEKTT DKVVCVYINC QLHTTRFGIF SQIHKKIFGH QPPETGVPFS
     RVYEKVMDKL SSDGKSLIVA FDDVNYLFQT PHANKVFYDI LRAYEEYEGV RTGIFAILSD
     LEFRFALDKN VNTVFIPQDI VFPPYNYSEI FSILKDRAKA GFFPGVVSDE IIEEIANQTY
     EVGDLRVGID LLRVSGNIAE SNASRTIELE HVEEAVAKQG SVNLMETINS LNDLEKTMIK
     VLIDRDEVVT AGALSKEFKE QAGVSYATFN RTLEKLEFLR LVDTRYTGKG VRGNSREIIL
     RFSPEDIKRC NL
//