ID D3E4M6_METRM Unreviewed; 699 AA.
AC D3E4M6;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=acetate--CoA ligase (ADP-forming) {ECO:0000256|ARBA:ARBA00012957};
DE EC=6.2.1.13 {ECO:0000256|ARBA:ARBA00012957};
GN Name=acs {ECO:0000313|EMBL:ADC47420.1};
GN OrderedLocusNames=mru_1570 {ECO:0000313|EMBL:ADC47420.1};
OS Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 /
OS OCM 146 / M1) (Methanobacterium ruminantium).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=634498 {ECO:0000313|EMBL:ADC47420.1, ECO:0000313|Proteomes:UP000008680};
RN [1] {ECO:0000313|EMBL:ADC47420.1, ECO:0000313|Proteomes:UP000008680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1
RC {ECO:0000313|Proteomes:UP000008680};
RX PubMed=20126622; DOI=10.1371/journal.pone.0008926;
RA Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J.,
RA Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C.,
RA Janssen P.H., Dey D., Attwood G.T.;
RT "The genome sequence of the rumen methanogen Methanobrevibacter ruminantium
RT reveals new possibilities for controlling ruminant methane emissions.";
RL PLoS ONE 5:E8926-E8926(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + ADP + phosphate;
CC Xref=Rhea:RHEA:15081, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456216; EC=6.2.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001619};
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DR EMBL; CP001719; ADC47420.1; -; Genomic_DNA.
DR RefSeq; WP_012956369.1; NC_013790.1.
DR AlphaFoldDB; D3E4M6; -.
DR STRING; 634498.mru_1570; -.
DR GeneID; 8771229; -.
DR KEGG; mru:mru_1570; -.
DR PATRIC; fig|634498.28.peg.1572; -.
DR eggNOG; arCOG01338; Archaea.
DR eggNOG; arCOG01340; Archaea.
DR HOGENOM; CLU_007415_3_1_2; -.
DR OrthoDB; 18103at2157; -.
DR Proteomes; UP000008680; Chromosome.
DR GO; GO:0043758; F:acetate-CoA ligase (ADP-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 2.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR043938; Ligase_CoA_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032875; Succ_CoA_lig_flav_dom.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR43334; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR PANTHER; PTHR43334:SF1; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR Pfam; PF13549; ATP-grasp_5; 1.
DR Pfam; PF13380; CoA_binding_2; 1.
DR Pfam; PF19045; Ligase_CoA_2; 1.
DR Pfam; PF13607; Succ_CoA_lig; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 2.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Ligase {ECO:0000313|EMBL:ADC47420.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000008680}.
FT DOMAIN 492..528
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 699 AA; 74687 MW; 038FE6E137B42E2C CRC64;
MTDLNKMFNP DSVAIVGASN SEGKVGYIIV NNMINDGFKG NIYPINPKDD EIQGLKAYKN
VSDLPEVPDL VIVSIPSVLV NPVVEECGEF GVKNMVVITA GFKEIGGDGV ERENQLVALG
EKYGINIIGP NSLGITDSHT PLNASFSQIM PPEGNIAFIS QSGAMMVAII DWSVTSGIGF
SKIISLGNKA GTTEIELIEY LSYDDETAVV ICYLESITED DDFVRTLRKV SYKKPVIILK
SGSSSAGAEA ASSHTGALAG SDIAFDTAFK QSGVFRVTTM DELFDVGLAF SKCPLPTGRN
LAIITNAGGG GVLSVDAMER YNLDLVKFDE KTNARLKEAV PEEGSIKNPI DVLGDAPVIR
YKESLEAVLD SDDVDGLVVM VCPTASADAD GIADALVEGA SGFDKPVIAV NMGGPIFENA
NDVLRDNGIP TYVFPETAVK VFDYLARFAA VQDRNYDDPV GELDDVDKEA VEEIFAKVKA
EERDTLLGSE AYAVAEAYGI EAAPIKLATS AEEAGQLAEE MEFPVVLKIA SDKILHKSDI
GGVKVGIQSK EEAEEVFEEI MANAKKAHPD IVPNGVEVQK MMDSGIEVLV GMVRDSQFGP
MIAFGMGGVL VNLLEDVSFK LAKGLTTDEI AEQMESTKVM GLLKGFRGEA PGDIEAVKSA
IIRIAKLTLD FPEISELDIN PIFVYEKGSS ALDIKIKLA
//
