ID D3GGP8_9BETR Unreviewed; 870 AA.
AC D3GGP8;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACX93977.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACX93977.1};
OS Ovine enzootic nasal tumor virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Betaretrovirus.
OX NCBI_TaxID=69576 {ECO:0000313|EMBL:ACX93977.1};
RN [1] {ECO:0000313|EMBL:ACX93977.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ENTV-1NA6 {ECO:0000313|EMBL:ACX93977.1};
RX PubMed=20398709; DOI=10.1016/j.virusres.2010.04.002;
RA Walsh S.R., Linnerth-Petrik N.M., Laporte A.N., Menzies P.I., Foster R.A.,
RA Wootton S.K.;
RT "Full-length genome sequence analysis of enzootic nasal tumor virus reveals
RT an unusually high degree of genetic stability.";
RL Virus Res. 151:74-87(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ744149; ACX93977.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd09273; RNase_HI_RT_Bel; 1.
DR CDD; cd01645; RT_Rtv; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 55..243
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 457..588
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 590..631
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 644..803
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 809..858
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 809..858
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACX93977.1"
SQ SEQUENCE 870 AA; 99323 MW; B4A43195327604B2 CRC64;
SRSKRLGVFS LGTSDSPVTH ADPIDWKSEE PVWVDQWPLT QEKLSAAQQL VQEQLRLGHI
EPSTSAWNSP IFVIKKKSGK WRLLQDLRKV NETMMHMGAL QPGLPTPSAI PDKSYIIVID
LKDCFYTIPL APQDCKRFAF SVPSVNFKEP MQRYQWKVLP QGMTNSPTLC QKFVATAIAP
VRQRFPQIYL VHYMDDILLA HTDEHLLYQA FSILKQHLSL NGLVIADEKI QTHFPYNYLG
FSLHPRTYNT QLVKLQTDHL KTLNDFQKLL GDINWIRPYL KLPTYTLQPL FDILKGDSDP
ASPRTLSLEG QTALQLIEEA IRQQQITYCD YQRSWGLYIL PTPRAPTGVL YQDKPLRWIY
LSATPTKHLL PYYELVAKIV AKGRHEAIQY FGMEPPLICV PYALEQQDWL FQFSDNWAIA
FANYPGRIIH HYPPDKLLQF ASSHAFIFPK IVRRQPIPNA TLIFTDGSSN GTAALIINHQ
TYYTQTSFSS AQVVELFAVH QALLTVPTSF NLFTDSSYVV GALQTIETVP IIGTTSPEVL
NLFTLIQQVL HCRQYPCFFG HIRAHSTLPG ALVRGNHTAD VLTKQVFFQS AIDAARKSHD
LHHQNSHSLR LQFKISREAA RQIVKSCSTC PQFFVLPQYG VNPRGLRPNH LWQTDVTHIP
QFGRLKYVHV SIDTFSNFLM ASLHTGESTR HCIQHLLFCF STSGIPQTLK TDNGPGYTSR
SFQRFCLSFQ IHHKTGIPYN PQGQGIVERA HQRLKHQLLK QKKGNELYSP SPYNALNHAL
YVLNFLTLDA EGNSAAQRFW GERSSCKKPL VRWKDPLTNL WYGPDPVLIW GRGHVCVFPQ
DAEAPRWIPE RLVRAAEELP DISNATHDIE
//
