ID   D3HRS4_LEGLN            Unreviewed;       746 AA.
AC   D3HRS4;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Putative integral membrane protein {ECO:0000313|EMBL:CBJ11603.1};
GN   OrderedLocusNames=LLO_1244 {ECO:0000313|EMBL:CBJ11603.1};
OS   Legionella longbeachae serogroup 1 (strain NSW150).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=661367 {ECO:0000313|EMBL:CBJ11603.1, ECO:0000313|Proteomes:UP000001060};
RN   [1] {ECO:0000313|EMBL:CBJ11603.1, ECO:0000313|Proteomes:UP000001060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NSW150 {ECO:0000313|EMBL:CBJ11603.1,
RC   ECO:0000313|Proteomes:UP000001060};
RX   PubMed=20174605; DOI=10.1371/journal.pgen.1000851;
RA   Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D.,
RA   Newton H., Sansom F., Jarraud S., Zidane N., Ma L., Bouchier C.,
RA   Etienne J., Hartland E., Buchrieser C.;
RT   "Analysis of the Legionella longbeachae genome and transcriptome uncovers
RT   unique strategies to cause Legionnaires' disease.";
RL   PLoS Genet. 6:E1000851-E1000851(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FN650140; CBJ11603.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3HRS4; -.
DR   STRING; 661367.LLO_1244; -.
DR   KEGG; llo:LLO_1244; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_5_2_6; -.
DR   Proteomes; UP000001060; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001060};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        24..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        559..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        586..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        626..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        675..697
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        703..728
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          121..372
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          522..737
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   746 AA;  84646 MW;  C1BF23F6ABEA158A CRC64;
     METPARKMSK KTLSYRLGKL INKLRWPIII FWVLVVLSCI PFLPHIIAPF KTTGFVDETS
     QSAKAELYMD KKLGYDDKNQ FIVMYHSPKL LATRTLFKKK MKQSLSELED FPIKHEIIYP
     DDKHQISKDK HTAYAVIIIK TNKPINDQLL KQFKDSIKKP SNMTMQIGGE PLFVQNVNKQ
     TQTDLYKADF IATPVAIVTL VVVFGSVVAA TLPIILGGGC ALIILTTLYF LGHFFTLSIF
     TINIALLLGL CLCLDYSLFF ISRFRDELKN GSSVEEAIGT SQETAGKAIF FSGLAVFVSL
     SALFLFPVNI LFSVAVGGLA AVFYAVLIST ILLPAILAVL KTKINFLSVR IFRNKNHSSY
     WRWLAERVVN HPYRFFFPIL IFLLLLGYPF LKANFGISDY RIFPINSENR AFYDTYAEKF
     NIEELNPIVL VVESPSSPIL SRHNLSKIYD FVHKLEQNPL VKEVNGIISS DSDVKKSQYY
     TLYHMNKKLL DSQVRRLLET TTTKHLTVIR VVSKYPANSP ETKKLITQLY HMKVGPGLTM
     ELTGTAVSNS DVLKSIYHFL PYSILWIMVF SYLILLLLLR SIFLPLKAII MTLLSLCASY
     GALVLVFQDG YFSQILNFQP QNMLDISLLV IIFCALFGFS MDYEVFLLSR IKEAHQLTKH
     NNNSIIFGIE KSSRIITSAA LIVIVISCSF LVADVLMVKA FGLGIAVAIF VDAFLIRSFL
     VPATMAIFKN WVWYLPKWLD RILPKI
//