ID D3ICB4_9BACT Unreviewed; 531 AA.
AC D3ICB4;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=HMPREF0669_01068 {ECO:0000313|EMBL:EFC70613.1};
OS Prevotella sp. oral taxon 299 str. F0039.
OG Plasmid unnamed {ECO:0000313|EMBL:EFC70613.1}.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=575614 {ECO:0000313|EMBL:EFC70613.1, ECO:0000313|Proteomes:UP000015929};
RN [1] {ECO:0000313|EMBL:EFC70613.1, ECO:0000313|Proteomes:UP000015929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0039 {ECO:0000313|EMBL:EFC70613.1,
RC ECO:0000313|Proteomes:UP000015929};
RC PLASMID=unnamed {ECO:0000313|EMBL:EFC70613.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFC70613.1, ECO:0000313|Proteomes:UP000015929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0039 {ECO:0000313|EMBL:EFC70613.1,
RC ECO:0000313|Proteomes:UP000015929};
RC PLASMID=Plasmid {ECO:0000313|Proteomes:UP000015929};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Tanner A.C., Dewhirst F.E., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Prevotella sp. Oral Taxon 299 strain F0039.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CP003667; EFC70613.1; -; Genomic_DNA.
DR RefSeq; WP_009228244.1; NC_022111.1.
DR AlphaFoldDB; D3ICB4; -.
DR KEGG; pro:HMPREF0669_01068; -.
DR HOGENOM; CLU_007082_5_1_10; -.
DR OrthoDB; 9794261at2; -.
DR Proteomes; UP000015929; Plasmid.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 2.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Plasmid {ECO:0000313|EMBL:EFC70613.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015929};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..531
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003046540"
FT DOMAIN 26..144
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 147..489
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 319
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 531 AA; 61234 MW; 778013197B3ECB4B CRC64;
MTKLNIFKLV ALCYFCFFFS ASHAQGVIPQ PQKVTLTQGY TELDAPLAWH PKTARRNRKQ
FDYILTELQK HTNSTGKAKL LRLNNTAIAS QKLSFHEEQG YKLEITPNEI TISSPSDVGL
FYGLQTLQQL CFSKRIACQV IEDAPKYDYR GWMLDCSRHF FSKEFVYKQI DAMALLKLNK
LHLHLVDGGG WRIEMKQFPW LTRKGAYRTH SDWDEWIDAG RRFCEPDYPG AYGGFYTKKD
LKDIINYAAK RFIMVIPEIE MPGHSNEVMA VYPELSCTGK GDGFDLCMGN PDTEVFLKKV
LTEVMELFPA PYIHIGGDEA TMRFWKNCPK CKQMMQKHNY TDTLQLQGRL ILAIDSFVTK
YGKSIIGWDE IQESGKLSQN AVVMSWRGEQ GGLHAAKAQH RVVITPSKRY YLDAYQDNPS
SQPRAIGGFT LLRNAYEYEP MPKEIENTDA SKYIWGIQGN LWTEYIDTER YAEYMTYPRL
LAIAESAWGT KTSYDAFKLR VIPFVNQLRK KGYNAFDITK EIGRKIETNK K
//
