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Database: UniProt
Entry: D3K2J1_9HIV1
LinkDB: D3K2J1_9HIV1
Original site: D3K2J1_9HIV1 
ID   D3K2J1_9HIV1            Unreviewed;       288 AA.
AC   D3K2J1;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:ADB96061.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ADB96061.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ADB96061.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ADB96061.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19336453; DOI=10.1093/jac/dkp114;
RA   Wittkop L., Breilh D., Da Silva D., Duffau P., Mercie P., Raymond I.,
RA   Anies G., Fleury H., Saux M.C., Dabis F., Fagard C., Thiebaut R.,
RA   Masquelier B., Pellegrin I.;
RT   "Virological and immunological response in HIV-1-infected patients with
RT   multiple treatment failures receiving raltegravir and optimized background
RT   therapy, ANRS CO3 Aquitaine Cohort.";
RL   J. Antimicrob. Chemother. 63:1251-1255(2009).
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DR   EMBL; GU358400; ADB96061.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF00552; IN_DBD_C; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   4: Predicted;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          3..44
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          54..204
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51027"
FT   DNA_BIND        223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADB96061.1"
SQ   SEQUENCE   288 AA;  32309 MW;  602CDB3888DC8555 CRC64;
     FLDGIDKAQE DHEKYHTNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM HGQVDCSPGI
     WQLDCTHLEG KIILVAVHVS SGYIEAEVIP AETGQETAYF ILKLAGRWPV XTIHTDNGXN
     FXSXTVKAAC WWAGIKQEFG IPYNPQSQGV VESMNKELKK IIGQVRDQAE HLKTAVQMAV
     FIHNFKRKGG IGGYSAGERI VDIIAXDIQT KELQKQITKI QNFRVYYRDS RDPLWKGPAK
     LLWKGEGAVV IQDNSEIKVV PRRKAKIIRD YGKQMAGDDC VASRQEED
//
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