ID D3K341_SUBDO Unreviewed; 555 AA.
AC D3K341;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Iroquois homeodomain protein b {ECO:0000313|EMBL:ADC29553.1};
DE Flags: Fragment;
GN Name=Irx-b {ECO:0000313|EMBL:ADC29553.1};
OS Suberites domuncula (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC Suberitidae; Suberites.
OX NCBI_TaxID=55567 {ECO:0000313|EMBL:ADC29553.1};
RN [1] {ECO:0000313|EMBL:ADC29553.1}
RP NUCLEOTIDE SEQUENCE.
RA Stifanic M., Pfannkuchen M.A., Batel R., Mueller W.E.G.;
RT "Iroquois homeobox genes (Irx) in the marine sponge Suberites domuncula and
RT analysis of Irx sequences from sponges to humans.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; GU361775; ADC29553.1; -; Transcribed_RNA.
DR AlphaFoldDB; D3K341; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11850:SF102; HOMEOBOX PROTEIN HOMOTHORAX; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 2.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 28..64
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 191..225
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 30..65
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 193..226
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 134..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADC29553.1"
SQ SEQUENCE 555 AA; 59707 MW; 54A13DBE1E433605 CRC64;
PQRSTSSGPQ KRRNPAVLVL WIKEHSANPY PTKAEKDFLA HDANMTQRQL KDWFINVRRV
IKKIGYEKWN SSYSACFSMP PTATADGSIS TRQAAAPTLS VPSNTCGNIN SRGLNHLPSA
SLLLEENRLA RGSPSYIESG IPPHQPDEHS ERAVVNGQSP SPQRSTSSGP RKRCNPAVLV
LWIEEHSANL YPTKAEKNFL AHYANMTTCQ LNDWFLNARR SIKKIGYEKW KEKHSSYSAR
FSMPRPATAD GSRSTRLAQF PMKIAGGLND VGLCDSDGLK LASINYGGND APLAAAPTLS
VPSNTCGNIN SRPFPYLLSP QSSLVNVGGT HPQAANTQVA MDPTAYYQVQ HPSAGAGIRP
VQPASGISLP PSGISFSPMS GPNVSLFSST GRPGSMPPQF TPSPISIATP WTDNAAVSDA
PLVKQVRGKV INKPHAHSPP VKLQVSPLLV STHVQRSPSP KDSDTTSNNS PHPATDLRPN
FASPTTAEST WAATLPLASS SQHIFKDSIS GGVGTQPGNQ ESDRQWGPQA WSNAYILSAG
SIAPSSNRKE LKRKL
//
