ID D3LVB1_9FIRM Unreviewed; 866 AA.
AC D3LVB1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EFD93838.1};
GN ORFNames=HMPREF0889_0232 {ECO:0000313|EMBL:EFD93838.1};
OS Megasphaera genomosp. type_1 str. 28L.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=699218 {ECO:0000313|EMBL:EFD93838.1, ECO:0000313|Proteomes:UP000003242};
RN [1] {ECO:0000313|Proteomes:UP000003242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28L {ECO:0000313|Proteomes:UP000003242};
RA Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RT "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFD93838.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADGP01000020; EFD93838.1; -; Genomic_DNA.
DR RefSeq; WP_009369790.1; NZ_ADGP01000020.1.
DR AlphaFoldDB; D3LVB1; -.
DR STRING; 699218.HMPREF0889_0232; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000003242; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 866 AA; 97364 MW; 3DEC595407557E7D CRC64;
MAEAIKLTPM MKQYMEVKER CRDKILFFRL GDFYEMFFED ALTVSRELDL TLTGRAGGNK
EKVPMCGVPF HSADTYIERL VQKGYKVAVC EQMEDPKAAK GIVKREIIKV ITPGTITMEH
AVAAKQNNYL ACMTASAASV SFVLADVTTG ECWWQVCDTD GWESIVGDMV SVYAPRELLL
GSLTAAQKDG IRKILQQREG NCVLTEPDIR TDVDYEAVGT QYFTVEMMAA AKAASYCLGL
LLSYVTEVMK CDISYFHTLE PLQQEQRLVL DAACLHHLEI TRNVRDGGRK GTLLAVLDHT
CTAMGGRLLR KWLETPLLSG TQIMRRQEGV AELVQHSVLR KDVTDILEKI YDFERILTRI
ETGTVSPKDY VALRESLGVL PTLKQALQQV TSPILRDLIA AVHTHDEVYD LLCRSIKEVP
GQVIRNGGVI REGFSSELDE IRRIGANSKE FLQELEAKER ERTGIKMKIG YTKVFGYYFE
ISHANTKPVP EYYIRKQTLV NAERYITPAL KEFEVKVLTA QERMLALEYA LYGEVRQRIQ
THIHDMQETA RALAQLDCLH SLAVAAQENR YIRPQLNGER QIRIVDGRHP IMEHYVKNAL
FVPNDVVLNH DTHEILIITG PNMAGKSTYM RQVAVLVLMT QIGSFIPARE ASICPVDRIF
TRIGATDDIL TGQSTFMMEM EEVSHILQYA TQNSLLILDE IGRGTSTFDG MSIARAVIEY
CLKKVHALTL FATHYHELTD MSTMSKKIKN YTVAVKERGR DITFLRRIIP GGADRSYGLH
VARLAGLPEG LLKRAEVILQ ELETAEHRPC QVSPSEKRDT VGAEGLFANP VLTRLLEVDI
NGLTPIEAIS FLYALQKEAK EGSGVG
//
