ID D3P6S6_AZOS1 Unreviewed; 400 AA.
AC D3P6S6;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Efflux transporter {ECO:0000313|EMBL:BAI76355.1};
GN OrderedLocusNames=AZL_e00100 {ECO:0000313|EMBL:BAI76355.1};
OS Azospirillum sp. (strain B510).
OG Plasmid pAB510e {ECO:0000313|EMBL:BAI76355.1,
OG ECO:0000313|Proteomes:UP000002040}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Azospirillum.
OX NCBI_TaxID=137722 {ECO:0000313|EMBL:BAI76355.1, ECO:0000313|Proteomes:UP000002040};
RN [1] {ECO:0000313|EMBL:BAI76355.1, ECO:0000313|Proteomes:UP000002040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B510 {ECO:0000313|EMBL:BAI76355.1,
RC ECO:0000313|Proteomes:UP000002040};
RC PLASMID=pAB510e {ECO:0000313|EMBL:BAI76355.1};
RX PubMed=20047946; DOI=10.1093/dnares/dsp026;
RA Kaneko T., Minamisawa K., Isawa T., Nakatsukasa H., Mitsui H.,
RA Kawaharada Y., Nakamura Y., Watanabe A., Kawashima K., Ono A., Shimizu Y.,
RA Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M., Nakazaki N.,
RA Nakayama S., Yamada M., Tabata S., Sato S.;
RT "Complete genomic structure of the cultivated rice endophyte Azospirillum
RT sp. B510.";
RL DNA Res. 17:37-50(2010).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; AP010951; BAI76355.1; -; Genomic_DNA.
DR RefSeq; WP_012978158.1; NC_013859.1.
DR AlphaFoldDB; D3P6S6; -.
DR KEGG; azl:AZL_e00100; -.
DR HOGENOM; CLU_018816_2_1_5; -.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000002040; Plasmid pAB510e.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Plasmid {ECO:0000313|EMBL:BAI76355.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002040};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 40..368
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 64..231
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 106..133
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 400 AA; 42132 MW; D551A89D56A2C031 CRC64;
MSRSNPFMTV AAAACLIAVL AGCNQQKQAG GQPQGGGPPE VSVVTIEPQR LTVSTELPGR
TAAYRVAEIR PQVSGIVLKR LFREGSDVKA GDQLYQIDPA TYEASLASAQ ADVQKAEANL
QAARNKAARY SDLVKTSVVS KQDFDDVQAS LKQNEAQVSA AKAAYNLANI NLNYTKVFAP
ISGRIGKSAV TEGALVTANQ ATALATIQQF DPIYVDVTQT ASQLMKLRDD MATGRIRPAE
PGKIPVTLFL NSNASGDDTA YPQKGELQFS DVTVDSGTSS VQLRAVFPNP TKELLPGLFV
RARVEQGVAE NAITVPQAAV ARGPDGSARV WVVGADNKVA PRPIKAERPV GNVWLVSDGL
AAGERVVVEG LQKVRPGAEV KPVPAQNALA ALPEKAASAR
//
