GenomeNet

Database: UniProt
Entry: D3PRT5_MEIRD
LinkDB: D3PRT5_MEIRD
Original site: D3PRT5_MEIRD 
ID   D3PRT5_MEIRD            Unreviewed;       459 AA.
AC   D3PRT5;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=Coproporphyrinogen III oxidase {ECO:0000256|RuleBase:RU364052};
DE            EC=1.3.3.15 {ECO:0000256|RuleBase:RU364052};
GN   OrderedLocusNames=Mrub_1406 {ECO:0000313|EMBL:ADD28168.1};
GN   ORFNames=K649_06690 {ECO:0000313|EMBL:AGK04638.1};
OS   Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus
OS   ruber).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX   NCBI_TaxID=504728 {ECO:0000313|EMBL:AGK04638.1, ECO:0000313|Proteomes:UP000013026};
RN   [1] {ECO:0000313|EMBL:ADD28168.1, ECO:0000313|Proteomes:UP000006655}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC   {ECO:0000313|Proteomes:UP000006655}, and DSM 1279
RC   {ECO:0000313|EMBL:ADD28168.1};
RX   PubMed=21304689; DOI=10.4056/sigs.1032748;
RA   Tindall B.J., Sikorski J., Lucas S., Goltsman E., Copeland A.,
RA   Glavina Del Rio T., Nolan M., Tice H., Cheng J.F., Han C., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A.,
RA   Fahnrich R., Goodwin L., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Chang Y.J., Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Meiothermus ruber type strain (21).";
RL   Stand. Genomic Sci. 3:26-36(2010).
RN   [2] {ECO:0000313|EMBL:AGK04638.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 1279 {ECO:0000313|EMBL:AGK04638.1};
RA   Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J.,
RA   Eichler E., Turner S.W.;
RT   "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT
RT   Sequencing Data.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AGK04638.1, ECO:0000313|Proteomes:UP000013026}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC   {ECO:0000313|Proteomes:UP000013026}, and DSM 1279
RC   {ECO:0000313|EMBL:AGK04638.1};
RA   Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.;
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in coproporphyrin-dependent heme b biosynthesis.
CC       Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin
CC       III. {ECO:0000256|RuleBase:RU364052}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2;
CC         Xref=Rhea:RHEA:43436, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57309, ChEBI:CHEBI:131725; EC=1.3.3.15;
CC         Evidence={ECO:0000256|RuleBase:RU364052};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|RuleBase:RU364052};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis. {ECO:0000256|RuleBase:RU364052}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364052}.
CC   -!- SIMILARITY: Belongs to the protoporphyrinogen/coproporphyrinogen
CC       oxidase family. Coproporphyrinogen III oxidase subfamily.
CC       {ECO:0000256|RuleBase:RU364052}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001743; ADD28168.1; -; Genomic_DNA.
DR   EMBL; CP005385; AGK04638.1; -; Genomic_DNA.
DR   RefSeq; WP_013013687.1; NC_021081.1.
DR   AlphaFoldDB; D3PRT5; -.
DR   STRING; 504728.K649_06690; -.
DR   KEGG; mrb:Mrub_1406; -.
DR   KEGG; mre:K649_06690; -.
DR   PATRIC; fig|504728.9.peg.1376; -.
DR   eggNOG; COG1232; Bacteria.
DR   OMA; WFDQWFG; -.
DR   OrthoDB; 9805195at2; -.
DR   UniPathway; UPA00252; -.
DR   Proteomes; UP000006655; Chromosome.
DR   Proteomes; UP000013026; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004729; F:oxygen-dependent protoporphyrinogen oxidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.10.3110.10; protoporphyrinogen ix oxidase, domain 3; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR004572; Protoporphyrinogen_oxidase.
DR   NCBIfam; TIGR00562; proto_IX_ox; 1.
DR   PANTHER; PTHR42923; PROTOPORPHYRINOGEN OXIDASE; 1.
DR   PANTHER; PTHR42923:SF3; PROTOPORPHYRINOGEN OXIDASE; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU364052};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU364052};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU364052};
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133,
KW   ECO:0000256|RuleBase:RU364052};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364052,
KW   ECO:0000313|EMBL:ADD28168.1}.
FT   DOMAIN          12..445
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
SQ   SEQUENCE   459 AA;  49306 MW;  01D15454A3BBA72D CRC64;
     MASVVVVGGG AAGLSTAYYL HRAAPHLHIT LLEADARLGG KITTVAEHGF VLEGGPDAVV
     RYKPWALELM HQLGLENQIV GTKPAHPSAL IHDGREALPI PAGLQMVIPG DLKALAQSPL
     LSPFGKARAA LELLLPKGTP EDEPFGAFIE RRLGRQVWER LVAPLSGGIY GGDPYELSTL
     AAFPQLKALE QQHGSLIRGA IQQRKARGSR EKGQLFASLE GGLGRLVEAI QARLGRVEIR
     LNTTVTALER SGGWRIHTTQ GSLQADALVL ATPAPVTGCL LEPLHPEAAA ALRQIPYGPS
     STVTFAFAKE KLPPRVGHGM LMAAHRGFSV RGFTWADQKW PGRAPEGYGL VRAYFSGLEA
     SKEELAQLAL RDLARLWGQV PEPLHTWVFR WPEGLPRYTV GHRERVAQAL KAEELSGLFL
     VGAAYQGVGL PEVIRMGQEV AERVLAYTGA QARDGAPVG
//
DBGET integrated database retrieval system