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Database: UniProt
Entry: D3QZT8_MAGIU
LinkDB: D3QZT8_MAGIU
Original site: D3QZT8_MAGIU 
ID   D3QZT8_MAGIU            Unreviewed;       438 AA.
AC   D3QZT8;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   25-OCT-2017, entry version 58.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADC91834.1};
GN   OrderedLocusNames=HMPREF0868_0093 {ECO:0000313|EMBL:ADC91834.1};
OS   Mageeibacillus indolicus (strain UPII9-5) (Clostridiales genomosp.
OS   BVAB3 (strain UPII9-5)).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Mageeibacillus.
OX   NCBI_TaxID=699246 {ECO:0000313|EMBL:ADC91834.1, ECO:0000313|Proteomes:UP000008234};
RN   [1] {ECO:0000313|Proteomes:UP000008234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UPII9-5 {ECO:0000313|Proteomes:UP000008234};
RA   Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Strausberg R.L., Nelson K.E.;
RT   "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001850; ADC91834.1; -; Genomic_DNA.
DR   RefSeq; WP_012992638.1; NC_013895.2.
DR   ProteinModelPortal; D3QZT8; -.
DR   STRING; 699246.HMPREF0868_0093; -.
DR   EnsemblBacteria; ADC91834; ADC91834; HMPREF0868_0093.
DR   KEGG; clo:HMPREF0868_0093; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008234; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008234};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008234}.
FT   DOMAIN      133    266       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      344    413       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     141    148       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  49599 MW;  6505A1D677C43493 CRC64;
     MPIIAKDLWN QALIKIAKEI PEITFKTWIA PLKAVSCEGD TFVLEAPNEF NRDQVKQYEA
     FFRNALMSIV PVQFHIKLTY EGAETPTKNT FSLPQTSIEG NINPAFTFDN FIVGSSNAHA
     HAACVSVAQN SRVFNPLFLY GGSGLGKTHL LHAIGNYVKQ HQPEKHIIYV PCEQFVNEFI
     RTIRENSYDS FRQKYRNCDM LLIDDIQFIE SKEQMQIEFF STFNALTENG SNIIMTCDKP
     PHSLSSLEER LRTRFASGVI VDINIPNFET RVAILQKRAE FLNIQVSYDI LEYIAHNFVS
     SIRELEGAFT TVISYSYISG KLDLSVAKAA LNNLISPSKR KSMTPETIIP IVARYFNFTE
     DEIKSKNKNK DLAIARQVTM YLLTKHSDLT YEQIGKIIGG KHHSTVMYGF NKINDEIKGG
     NQTIISAVND LNQRILGG
//
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