ID D3S2U0_FERPA Unreviewed; 345 AA.
AC D3S2U0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ADC66652.1};
GN OrderedLocusNames=Ferp_2547 {ECO:0000313|EMBL:ADC66652.1};
OS Ferroglobus placidus (strain DSM 10642 / AEDII12DO).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Ferroglobus.
OX NCBI_TaxID=589924 {ECO:0000313|EMBL:ADC66652.1, ECO:0000313|Proteomes:UP000002613};
RN [1] {ECO:0000313|Proteomes:UP000002613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10642 / AEDII12DO {ECO:0000313|Proteomes:UP000002613};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Tapia R.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Holmes D.,
RA Lovley D., Kyrpides N., Anderson I.J., Woyke T.;
RT "Complete sequence of Ferroglobus placidus DSM 10642.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADC66652.1, ECO:0000313|Proteomes:UP000002613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10642 / AEDII12DO {ECO:0000313|Proteomes:UP000002613};
RX PubMed=22180810; DOI=10.4056/sigs.2225018;
RA Anderson I., Risso C., Holmes D., Lucas S., Copeland A., Lapidus A.,
RA Cheng J.F., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Woyke T.,
RA Lovley D., Kyrpides N., Ivanova N.;
RT "Complete genome sequence of Ferroglobus placidus AEDII12DO.";
RL Stand. Genomic Sci. 5:50-60(2011).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001899; ADC66652.1; -; Genomic_DNA.
DR RefSeq; WP_012966984.1; NC_013849.1.
DR AlphaFoldDB; D3S2U0; -.
DR STRING; 589924.Ferp_2547; -.
DR PaxDb; 589924-Ferp_2547; -.
DR GeneID; 8780092; -.
DR KEGG; fpl:Ferp_2547; -.
DR eggNOG; arCOG00662; Archaea.
DR HOGENOM; CLU_041526_0_0_2; -.
DR OrthoDB; 73529at2157; -.
DR Proteomes; UP000002613; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034405; F420.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR016779; rSAM_MSMEG0568.
DR PANTHER; PTHR43076; FO SYNTHASE (COFH); 1.
DR PANTHER; PTHR43076:SF1; LIPOYL SYNTHASE 2; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01107; Uncharacterised_Radical_SAM_Su; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002613};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 101..323
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 345 AA; 38545 MW; ED957C77EB184FD6 CRC64;
MLDWRTKLEI IVKGVRGNVR SYRKSGGGPT GGVGFEVEGS VVSAPNKQKF VENSPYRIEK
IDEKYYLFKN DEVVGEVKLP KAEYYSKPTS FGVEAGKIVA LDGINALVTA VSRRCVLWKK
KRCKFCSIEI GLENSIVEKT PEMIAEAAKM AYEEDNSRHL TITSGIMPGK DKGAVKISEV
VKAVKEKVDI PIHVQVDVVD RDFLEMLYES GADTIGIHAE VLDEKIRSNV VPGKPKLEEY
FKAWENAVDI FGKWKVNSWI VLGFGEDKFV TAENVERMVE IGITPFLAPY RPPPYSNEQP
VNLDEVVKIY ELVESYVKHV KINKAEAGCF TCGGCTAVKE LIAKR
//
