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Database: UniProt
Entry: D3TK11_HBV
LinkDB: D3TK11_HBV
Original site: D3TK11_HBV 
ID   D3TK11_HBV              Unreviewed;       528 AA.
AC   D3TK11;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   Name=S {ECO:0000313|EMBL:ACN29781.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:ACN29781.1, ECO:0000313|Proteomes:UP000124249};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:ACN29781.1, ECO:0000313|Proteomes:UP000124249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Huang S.-F.K., Yeh C.-T., Chen Y.-T., Ku Y.-C., Chiu Y.-T., Hsu H.-Y.,
RA   Hsieh W.-Y.;
RT   "Study of Hepatitis B virus sequences in the HBcAg-positive hepatocellular
RT   carcinoma.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; EU882001; ACN29781.1; -; Genomic_DNA.
DR   Proteomes; UP000124249; Genome.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          42..285
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   528 AA;  59442 MW;  C29893E9C3CB052C CRC64;
     MQWNSTTCWW LQFRNSEPCS EYCLCHIVNL IEDWGPCTEH GEHRIRTPRT PARVTGGVFL
     VDKNPHNTTE SRLVVDFSQF SRGNTRVSWP KFAVPNLQSL TNLLSTNLSW LSLDVSAAFY
     HLPLHPAAMP HLLVGSSGLS RYVARLSSNS RIINNQHRTM QNLHDSCSRN LYVSLMLLYK
     TYGRKLHLYS HPIILGFRKI PMGVGLSPFL LAQFTSAICS VVRRAFPHCL AFSYMDDVVL
     GAKSVQHLES LYTAVTNFLL SLGIHLNPHK TKRWGYSLNF MGYVIGCWGT LPQEHIVHKI
     KMCFRKLPVN RPIDWKVCQR IVGLLGFAAP FTQCGYPALM PLYACIQAKQ AFTFSPTYKA
     FLSKQYLHLY PVARQRSGLC QVFADATPTG WGLAIGHQRM RGTFVSPLPI HTAELLAACF
     ARSRSGAKLI GTDNSVVLSR KYTSFPWLLG CAANWILRGT SFVYVPSALN PADDPSRGRL
     GLYRPLLRLV YRPTTGRTSL YADSPSVPSH LPDRVHFASP LHVAWKPP
//
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