ID D3TK11_HBV Unreviewed; 528 AA.
AC D3TK11;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=S {ECO:0000313|EMBL:ACN29781.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACN29781.1, ECO:0000313|Proteomes:UP000124249};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ACN29781.1, ECO:0000313|Proteomes:UP000124249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Huang S.-F.K., Yeh C.-T., Chen Y.-T., Ku Y.-C., Chiu Y.-T., Hsu H.-Y.,
RA Hsieh W.-Y.;
RT "Study of Hepatitis B virus sequences in the HBcAg-positive hepatocellular
RT carcinoma.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EU882001; ACN29781.1; -; Genomic_DNA.
DR Proteomes; UP000124249; Genome.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 42..285
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 528 AA; 59442 MW; C29893E9C3CB052C CRC64;
MQWNSTTCWW LQFRNSEPCS EYCLCHIVNL IEDWGPCTEH GEHRIRTPRT PARVTGGVFL
VDKNPHNTTE SRLVVDFSQF SRGNTRVSWP KFAVPNLQSL TNLLSTNLSW LSLDVSAAFY
HLPLHPAAMP HLLVGSSGLS RYVARLSSNS RIINNQHRTM QNLHDSCSRN LYVSLMLLYK
TYGRKLHLYS HPIILGFRKI PMGVGLSPFL LAQFTSAICS VVRRAFPHCL AFSYMDDVVL
GAKSVQHLES LYTAVTNFLL SLGIHLNPHK TKRWGYSLNF MGYVIGCWGT LPQEHIVHKI
KMCFRKLPVN RPIDWKVCQR IVGLLGFAAP FTQCGYPALM PLYACIQAKQ AFTFSPTYKA
FLSKQYLHLY PVARQRSGLC QVFADATPTG WGLAIGHQRM RGTFVSPLPI HTAELLAACF
ARSRSGAKLI GTDNSVVLSR KYTSFPWLLG CAANWILRGT SFVYVPSALN PADDPSRGRL
GLYRPLLRLV YRPTTGRTSL YADSPSVPSH LPDRVHFASP LHVAWKPP
//