ID D3UIV0_HELM1 Unreviewed; 343 AA.
AC D3UIV0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=N-acetylneuraminic acid synthetase {ECO:0000313|EMBL:CBG40425.1};
DE EC=4.1.3.- {ECO:0000313|EMBL:CBG40425.1};
GN Name=neuB3 {ECO:0000313|EMBL:CBG40425.1};
GN OrderedLocusNames=HMU11700 {ECO:0000313|EMBL:CBG40425.1};
OS Helicobacter mustelae (strain ATCC 43772 / LMG 18044 / NCTC 12198 / 12198)
OS (Campylobacter mustelae).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=679897 {ECO:0000313|EMBL:CBG40425.1, ECO:0000313|Proteomes:UP000001522};
RN [1] {ECO:0000313|EMBL:CBG40425.1, ECO:0000313|Proteomes:UP000001522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43772 / LMG 18044 / NCTC 12198 / 12198
RC {ECO:0000313|Proteomes:UP000001522};
RX PubMed=20219135; DOI=10.1186/1471-2164-11-164;
RA O'Toole P.W., Snelling W.J., Canchaya C., Forde B.M., Hardie K.R.,
RA Josenhans C., Graham R.L.J., McMullan G., Parkhill J., Belda E.,
RA Bentley S.D.;
RT "Comparative genomics and proteomics of Helicobacter mustelae, an
RT ulcerogenic and carcinogenic gastric pathogen.";
RL BMC Genomics 11:164-164(2010).
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DR EMBL; FN555004; CBG40425.1; -; Genomic_DNA.
DR RefSeq; WP_013023494.1; NC_013949.1.
DR AlphaFoldDB; D3UIV0; -.
DR STRING; 679897.HMU11700; -.
DR KEGG; hms:HMU11700; -.
DR eggNOG; COG2089; Bacteria.
DR HOGENOM; CLU_040465_0_1_7; -.
DR Proteomes; UP000001522; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR020030; Pseudaminic_synth_PseI.
DR InterPro; IPR013974; SAF.
DR NCBIfam; TIGR03586; PseI; 1.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR PANTHER; PTHR42966:SF2; PSEUDAMINIC ACID SYNTHASE; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CBG40425.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001522}.
FT DOMAIN 285..343
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 343 AA; 38510 MW; 6991ED1893815F14 CRC64;
MEKLTPSIPL LVAEISANHK QDLLLAKRHM QAAKHAGAHA IKIQTYRPSC LTLDSRDVIF
RIEGDSPWEG RYLYDLYAEA CLPWEWHGEL FAYAKEIGIE LFSSPFSLEA LELLESLNCP
RYKIASFECI DPLFIYEVAS TKKPIVLSTG IALEEEIKEA LEMCEKAGNS DITLLQCTSS
YPAPLKEANL LAMQRFGEYG VKFGLSDHTL GSLCAIIAAV LGASMIEKHF ILERSLGGVD
SSFSMEAEEF AQMAAQIQDS ILALGDPHHK KTLEELRGKR VFARSLFVKK PIKKGERFTR
ENIGSFRPNH GMHPRFFSDI LGRRASRDLE FAKPLLTQDI CKD
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