ID   D3W787_CYPCA            Unreviewed;       209 AA.
AC   D3W787;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   22-FEB-2023, entry version 49.
DE   RecName: Full=Suppressor of cytokine signaling 3 {ECO:0000256|ARBA:ARBA00021410};
GN   Name=SOCS-3 {ECO:0000313|EMBL:ADC96621.1};
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962 {ECO:0000313|EMBL:ADC96621.1};
RN   [1] {ECO:0000313|EMBL:ADC96621.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20025976; DOI=10.1016/j.fsi.2009.11.012;
RA   Xiao Z.G., Liu H., Fu J.P., Hu W., Wang Y.P., Guo Q.L.;
RT   "Cloning of common carp SOCS-3 gene and its expression during
RT   embryogenesis, GH-transgene and viral infection.";
RL   Fish Shellfish Immunol. 28:362-371(2010).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; GQ847548; ADC96621.1; -; mRNA.
DR   EMBL; GQ847549; ADC96622.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3W787; -.
DR   UniPathway; UPA00143; -.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd10384; SH2_SOCS3; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.750.20; SOCS box; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035863; SOCS3_SH2.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF11; SUPPRESSOR OF CYTOKINE SIGNALING 3; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          51..166
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          161..208
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   209 AA;  23886 MW;  5462D2E282913396 CRC64;
     MVTHSKFDNA MSSSLFDASM RLTSHHYKTF SSKLQFQMVQ HAVRMLQESG FYWGSISGKE
     ANHLLNSEPS GTFLVRDSSD NRHFFTLSVK TESGTKNLRV QCDNKSFFLQ TDSKSVQSVP
     RFDCVLKLVH YYMPSSRSPL SIGNSRNAYY IYTGGEKILL ELLRPLPCTM SSLQHLCRKT
     VNGHIDVSSK REQLPQQLKD FLQEYDAPI
//