ID D3W8V4_9HEPC Unreviewed; 665 AA.
AC D3W8V4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:ADC54704.1};
DE Flags: Fragment;
OS hepatitis C virus genotype 1a.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus hominis.
OX NCBI_TaxID=2847144 {ECO:0000313|EMBL:ADC54704.1};
RN [1] {ECO:0000313|EMBL:ADC54704.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1/910 {ECO:0000313|EMBL:ADC54704.1};
RX PubMed=19918975; DOI=10.1002/hep.23319;
RA Fuller M.J., Shoukry N.H., Gushima T., Bowen D.G., Callendret B.,
RA Campbell K.J., Hasselschwert D.L., Hughes A.L., Walker C.M.;
RT "Selection-driven immune escape is not a significant factor in the failure
RT of CD4 T cell responses in persistent hepatitis C virus infection.";
RL Hepatology 51:378-387(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; GQ870511; ADC54704.1; -; Genomic_RNA.
DR euHCVdb; GQ870511; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd20903; HCV_p7; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 6.10.250.1610; -; 1.
DR Gene3D; 6.10.250.1750; -; 1.
DR Gene3D; 2.30.30.710; Hepatitis C virus non-structural protein NS2, C-terminal domain; 1.
DR Gene3D; 1.20.1280.150; Hepatitis C virus non-structural protein NS2, N-terminal domain; 1.
DR InterPro; IPR002531; HCV_NS1.
DR InterPro; IPR002518; HCV_NS2.
DR InterPro; IPR042205; HCV_NS2_C.
DR InterPro; IPR042209; HCV_NS2_N.
DR InterPro; IPR004109; HepC_NS3_protease.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR Pfam; PF01560; HCV_NS1; 1.
DR Pfam; PF01538; HCV_NS2; 1.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51693; HCV_NS2_PRO; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..458
FT /note="Peptidase C18"
FT /evidence="ECO:0000259|PROSITE:PS51693"
FT DOMAIN 459..640
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADC54704.1"
FT NON_TER 665
FT /evidence="ECO:0000313|EMBL:ADC54704.1"
SQ SEQUENCE 665 AA; 73189 MW; DA3D157B6827E048 CRC64;
CVIGGAGNNT LHCPTDCFRK HPDATYSRCG SGPWITPRCL VDYPYRLWHY PCTINYTIFK
IRMYVGGVEH RLEAACNWTR GERCDLEDRD RSELSPLLLT TTQWQVLPCS FTTLPALSTG
LIHLHQDIVD VQYLYGVGSS IASWAIKWEY VVLLFLLLAD ARVCSCLWMM LLISQAEAAL
ENLVILNAAS LAGTHGLVSF LVFFCFAWYL KGKWVPGAVY TFYGMWPLLL LLLALPQRAY
ALDTEVAASC GGVVLVGLMA LTLSPYYKRY ISWCLWWLQY FLTRVEAQLH VWIPPLNVRG
GRDAVILLMC AVHPTLVFDI TKLLLAVFGP LWILQASLLK VPYFVRVQGL LRFCALARKM
IGGHYVQMVI IKLGALTGTY VYNHLTPLRD WAHNGLRDLA VAVEPVVFSQ METKLITWGA
DTAACGDIIN GLPVSARRGR EILLGPADGM VSKGWRLLAP ITAYAQQTRG LLGCIITSLT
GRDKNQVEGE VQIVSTAAQT FLATCINGVC WTVYHGAGTR TIASPKGPVI QMYTNVDQDL
VGWPAPQGSR SLTPCTCGSS DLYLVTRHAD VIPVRRRGDS RGSLLSPRPI SYLKGSSGGP
LLCPAGHAVG IFRAAVCTRG VAKAVDFIPV ENLETTMRSP VFTDNSSPPV VPESFQVAHL
HAPTG
//
