ID D3YPB2_HHV1 Unreviewed; 490 AA.
AC D3YPB2;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Alpha trans-inducing protein {ECO:0000256|ARBA:ARBA00030037};
DE AltName: Full=Alpha-TIF {ECO:0000256|ARBA:ARBA00033186};
GN Name=UL48 {ECO:0000313|EMBL:ADD60007.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:ADD60007.1, ECO:0000313|Proteomes:UP000121444};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADD60007.1, ECO:0000313|Proteomes:UP000121444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F {ECO:0000313|EMBL:ADD60007.1};
RX PubMed=20219902; DOI=10.1128/JVI.00312-10;
RA Szpara M.L., Parsons L., Enquist L.W.;
RT "Sequence variability in clinical and laboratory isolates of herpes simplex
RT virus 1 reveals new mutations.";
RL J. Virol. 84:5303-5313(2010).
CC -!- FUNCTION: May play a role in the aggregation of tegument proteins
CC around nucleocapsids during virus morphogenesis.
CC {ECO:0000256|ARBA:ARBA00002794}.
CC -!- SIMILARITY: Belongs to the herpesviridae tegument protein VP16 protein
CC family. {ECO:0000256|ARBA:ARBA00010001}.
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DR EMBL; GU734771; ADD60007.1; -; Genomic_DNA.
DR Proteomes; UP000121444; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.1290.10; Alpha trans-inducing (Alpha-TIF); 1.
DR InterPro; IPR003174; Alpha_TIF.
DR InterPro; IPR036538; Alpha_TIF_sf.
DR InterPro; IPR021051; HSV_VP16_C.
DR Pfam; PF02232; Alpha_TIF; 1.
DR Pfam; PF12149; HSV_VP16_C; 1.
DR SMART; SM00814; Alpha_TIF; 1.
DR SUPFAM; SSF56548; Conserved core of transcriptional regulatory protein vp16; 1.
PE 3: Inferred from homology;
FT DOMAIN 461..490
FT /note="Herpes simplex virus Tegument protein VP16 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12149"
FT REGION 12..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54346 MW; 54527B391196C2A0 CRC64;
MDLLVDELFA DMDADGASPP PPRPAGGPKN TPAAPPLYAT GRLSQAQLMP SPPMPVPPAA
LFNRLLDDLG FSAGPALCTM LDTWNEDLFS ALPTNADLYR ECKFLSTLPS DVVEWGDAYV
PERAQIDIRA HGDVAFPTLP ATRDGLGLYY EALSRFFHAE LRAREESYRT VLANFCSALY
RYLRASVRQL HRQAHMRGRD RDLGEMLRAT ITDRYYRETA RLARVLFLHL YLFLTREILW
AAYAEQMMRP DLFDCLCCDL ESWRQLAGLF QPFMFVNGAL TVRGVPIEAR RLRELNHIRE
HLNLPLVRSA ATEEPGAPLT TPPTLHGNQA RASGYFMVLI RAKLDSYSSF TTSPSEAVMR
EHAYSRARTK NNYGSTIEGL LDLPDDDAPE EAGLAAPRLS FLPAGHTRRL STAPPTDVSL
GDELHLDGED VAMAHADALD DFDLDMLGDG DSPGPGFTPH DSAPYGALDM ADFEFEQMFT
DALGIDEYGG
//
