ID D3YPG7_HHV1 Unreviewed; 473 AA.
AC D3YPG7;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Envelope glycoprotein M {ECO:0000313|EMBL:ADD60103.1};
GN Name=UL10 {ECO:0000313|EMBL:ADD60103.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:ADD60103.1, ECO:0000313|Proteomes:UP000126435};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADD60103.1, ECO:0000313|Proteomes:UP000126435}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H129 {ECO:0000313|EMBL:ADD60103.1};
RX PubMed=20219902; DOI=10.1128/JVI.00312-10;
RA Szpara M.L., Parsons L., Enquist L.W.;
RT "Sequence variability in clinical and laboratory isolates of herpes simplex
RT virus 1 reveals new mutations.";
RL J. Virol. 84:5303-5313(2010).
CC -!- FUNCTION: Envelope glycoprotein important for virion assembly and
CC egress. Plays a role in the correct incorporation of gH-gL into virion
CC membrane. Directs the glycoprotein N (gN) to the host trans-Golgi
CC network. {ECO:0000256|ARBA:ARBA00003017}.
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DR EMBL; GU734772; ADD60103.1; -; Genomic_DNA.
DR Proteomes; UP000126435; Genome.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04035; HSV_GM; 1.
DR InterPro; IPR000785; Herpes_glycop_M.
DR Pfam; PF01528; Herpes_glycop; 1.
DR PRINTS; PR00333; HSVINTEGRLMP.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADD60103.1};
KW Virion {ECO:0000313|EMBL:ADD60103.1}.
FT TRANSMEM 26..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 371..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 51376 MW; 671C956396BD2351 CRC64;
MGRPAPRGSP DSAPPTKGMT GVRTAWWVWC VQVATFVVSA VCVTGLLVLA SVFRARFPCF
YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV LLLAAAVYAV VGAVTSRYDR
ALDAGRRLAA ARMAMPHATL IAGNVCSWLL QITVLLLAHR ISQLAHLVYV LHFACLVYFA
AHFCTRGVLS GTYLRQVHGL MEPAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI
AAFNFNFSAP GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR HHTKFFMRMR
DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE DPYAISYGGQ LDRYGDSDGE
PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI YDTVGGYDPE PAEDPVYSTV RRW
//
