UniProt: D3YPK9

Database: UniProt
Entry: D3YPK9_HHV1

LinkDB:  D3YPK9_HHV1 
Original site:  D3YPK9_HHV1

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (50)   
   EMBL (50)   
Protein domain (4)   
   InterPro (3)   
   Pfam (1)   
Literature (8)   
   PubMed (8)   
All databases (66)   

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ID   D3YPK9_HHV1             Unreviewed;       371 AA.
AC   D3YPK9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Deoxyuridine triphosphatase {ECO:0000313|EMBL:ADD60121.1};
DE            EC=3.6.1.23 {ECO:0000313|EMBL:ADM23590.1, ECO:0000313|EMBL:AWO70126.1};
DE   SubName: Full=UL50 {ECO:0000313|EMBL:AER37845.1};
GN   Name=UL50 {ECO:0000313|EMBL:ADD60121.1};
GN   ORFNames=HHV1gp074 {ECO:0000313|EMBL:AFE62879.1};
OS   Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC   Simplexvirus humanalpha1.
OX   NCBI_TaxID=10298 {ECO:0000313|EMBL:ADD60121.1, ECO:0000313|Proteomes:UP000126435};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ADD60121.1, ECO:0000313|Proteomes:UP000126435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H129 {ECO:0000313|EMBL:ADD60121.1};
RX   PubMed=20219902; DOI=10.1128/JVI.00312-10;
RA   Szpara M.L., Parsons L., Enquist L.W.;
RT   "Sequence variability in clinical and laboratory isolates of herpes simplex
RT   virus 1 reveals new mutations.";
RL   J. Virol. 84:5303-5313(2010).
RN   [2] {ECO:0000313|EMBL:ADM23590.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R62 {ECO:0000313|EMBL:ADM23816.1}, S23
RC   {ECO:0000313|EMBL:ADM23590.1}, and S25 {ECO:0000313|EMBL:ADM23665.1};
RX   PubMed=22417106; DOI=10.1111/j.1749-6632.2011.06358.x;
RA   Davison A.J.;
RT   "Evolution of sexually transmitted and sexually transmissible human
RT   herpesviruses.";
RL   Ann. N. Y. Acad. Sci. 1230:E37-E49(2011).
RN   [3] {ECO:0000313|EMBL:AER37845.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CJ360 {ECO:0000313|EMBL:AER37845.1};
RX   PubMed=22016062; DOI=10.1167/iovs.11-7812;
RA   Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.;
RT   "Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes:
RT   phylogeny, sequence variability, and SNP distribution.";
RL   Invest. Ophthalmol. Vis. Sci. 52:9061-9073(2011).
RN   [4] {ECO:0000313|EMBL:AFE62879.1, ECO:0000313|Proteomes:UP000180972}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KOS {ECO:0000313|EMBL:AFE62879.1};
RX   PubMed=22570244; DOI=10.1128/JVI.00646-12;
RA   Macdonald S.J., Mostafa H.H., Morrison L.A., Davido D.J.;
RT   "Genome Sequence of Herpes Simplex Virus 1 Strain KOS.";
RL   J. Virol. 86:6371-6372(2012).
RN   [5] {ECO:0000313|EMBL:AFI23642.1, ECO:0000313|Proteomes:UP000107500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KOS {ECO:0000313|EMBL:AFI23642.1};
RA   Payne K.M., Russell D.A., Kinchington P.R.;
RT   "Complete genome sequence of Herpes Simplex Virus Type-1 strain KOS.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AGZ01913.1, ECO:0000313|Proteomes:UP000131150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RE {ECO:0000313|EMBL:AGZ01913.1};
RA   Payne K.M., Twaddle A.C.Jr., Russell D.A., Kinchington P.R.;
RT   "Genetic comparison of HSV-1 strains KOS and RE.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:ADM23590.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R62 {ECO:0000313|EMBL:ADM23816.1}, S23
RC   {ECO:0000313|EMBL:ADM23590.1}, and S25 {ECO:0000313|EMBL:ADM23665.1};
RA   Davison A.J.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AJE59996.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H166 {ECO:0000313|EMBL:AJE60352.1}, H166syn
RC   {ECO:0000313|EMBL:AJE60425.1}, and KOS {ECO:0000313|EMBL:AJE59996.1};
RX   PubMed=25827418;
RA   Parsons L.R., Tafuri Y.R., Shreve J.T., Bowen C.D., Shipley M.M.,
RA   Enquist L.W., Szpara M.L.;
RT   "Rapid genome assembly and comparison decode intrastrain variation in human
RT   alphaherpesviruses.";
RL   MBio 6:e02213-14(2015).
RN   [9] {ECO:0000313|Proteomes:UP000110586, ECO:0000313|Proteomes:UP000180950}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KOS {ECO:0000313|EMBL:ALO18648.1}, and KOS 1.1
RC   {ECO:0000313|EMBL:ALO18724.1};
RX   PubMed=26547038; DOI=10.1016/j.virol.2015.09.026;
RA   Colgrove R.C., Liu X., Griffiths A., Raja P., Deluca N.A., Newman R.M.,
RA   Coen D.M., Knipe D.M.;
RT   "History and genomic sequence analysis of the herpes simplex virus 1 KOS
RT   and KOS1.1 sub-strains.";
RL   Virology 487:215-221(2015).
RN   [10] {ECO:0000313|EMBL:ALM22842.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KOS63 {ECO:0000313|EMBL:ALM22842.1};
RA   Bowen C.D., Renner D.W., Shreve J.T., Tafuri Y., Payne K.M., Dix R.D.,
RA   Gatherer D., Kinchington P., Szpara M.L.;
RT   "Genetic Distance in Herpes Simplex Virus Isolates of the Same Lineage.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:SBS69483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3083/2008 {ECO:0000313|EMBL:SBS69483.1};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:SBS69483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3083/2008 {ECO:0000313|EMBL:SBS69483.1};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AWX34687.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HSV-v29_day-90_culture1 {ECO:0000313|EMBL:AWX34826.1},
RC   HSV-v29_day1_culture2 {ECO:0000313|EMBL:AWX34895.1},
RC   HSV-v29_day60_culture3 {ECO:0000313|EMBL:AWX34965.1},
RC   HSV-v29_site12_day3 {ECO:0000313|EMBL:AWX35037.1}, HSV-v29_site13_day2
RC   {ECO:0000313|EMBL:AWX35106.1}, HSV-v29_site13_day3
RC   {ECO:0000313|EMBL:AWX35178.1}, HSV-v29_site14_day2
RC   {ECO:0000313|EMBL:AWX35248.1}, HSV-v29_site16_day2
RC   {ECO:0000313|EMBL:AWX34687.1}, and HSV-v29_site18_day2
RC   {ECO:0000313|EMBL:AWX34755.1};
RA   Hurst M.R.H.;
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:AWX34687.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HSV-v29_day-90_culture1 {ECO:0000313|EMBL:AWX34826.1},
RC   HSV-v29_day1_culture2 {ECO:0000313|EMBL:AWX34895.1},
RC   HSV-v29_day60_culture3 {ECO:0000313|EMBL:AWX34965.1},
RC   HSV-v29_site12_day3 {ECO:0000313|EMBL:AWX35037.1}, HSV-v29_site13_day2
RC   {ECO:0000313|EMBL:AWX35106.1}, HSV-v29_site13_day3
RC   {ECO:0000313|EMBL:AWX35178.1}, HSV-v29_site14_day2
RC   {ECO:0000313|EMBL:AWX35248.1}, HSV-v29_site16_day2
RC   {ECO:0000313|EMBL:AWX34687.1}, and HSV-v29_site18_day2
RC   {ECO:0000313|EMBL:AWX34755.1};
RX   PubMed=29920588;
RA   Shipley M.M., Renner D.W., Ott M., Bloom D.C., Koelle D.M., Johnston C.,
RA   Szpara M.L.;
RT   "Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From
RT   Multiple Anatomic Sites Over Time.";
RL   J. Infect. Dis. 218:595-605(2018).
RN   [15] {ECO:0000313|EMBL:AWO70126.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HSV1-CULTURE-G9 {ECO:0000313|EMBL:AWO70126.1}, HSV1-CULTURE-I2
RC   {ECO:0000313|EMBL:AWO71152.1}, HSV1-ORIGINAL-G9
RC   {ECO:0000313|EMBL:AWO71063.1}, and HSV1-ORIGINAL-I2
RC   {ECO:0000313|EMBL:AWO70220.1};
RA   Greninger A.L., Roychoudhury P., Xie H., Casto A., Cent A., Pepper G.,
RA   Koelle D.M., Huang M.-L., Wald A., Johnston C., Jerome K.R.;
RT   "Ultrasensitive capture of human herpes simplex virus genomes directly from
RT   clinical samples reveals extraordinarily limited evolution in cell
RT   culture.";
RL   J. ISSAAS 0:0-0(2018).
RN   [16] {ECO:0000313|EMBL:AWW07818.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=2006-50683 {ECO:0000313|EMBL:AWW12335.1}, 2006-57683
RC   {ECO:0000313|EMBL:AWW12078.1}, 2007-1997
RC   {ECO:0000313|EMBL:AWW08718.1}, 2011-12689
RC   {ECO:0000313|EMBL:AWW12784.1}, 2011-12714
RC   {ECO:0000313|EMBL:AWW08330.1}, 2011-12715
RC   {ECO:0000313|EMBL:AWW09141.1}, 2011-12717
RC   {ECO:0000313|EMBL:AWW08420.1}, 2011-12719
RC   {ECO:0000313|EMBL:AWW10515.1}, 2011-12741
RC   {ECO:0000313|EMBL:AWW12876.1}, 2011-12742
RC   {ECO:0000313|EMBL:AWW12497.1}, 2011-17239
RC   {ECO:0000313|EMBL:AWW13154.1}, 2011-17275
RC   {ECO:0000313|EMBL:AWW11625.1}, 2011-21041
RC   {ECO:0000313|EMBL:AWW09704.1}, 2011-31164
RC   {ECO:0000313|EMBL:AWW07818.1}, 2011-31213
RC   {ECO:0000313|EMBL:AWW10156.1}, 2011-5409
RC   {ECO:0000313|EMBL:AWW10684.1}, 2011-5438
RC   {ECO:0000313|EMBL:AWW11353.1}, 2016-1040
RC   {ECO:0000313|EMBL:AWW12244.1}, and 29_2011-12691
RC   {ECO:0000313|EMBL:AWW11178.1};
RX   PubMed=29898986;
RA   Greninger A.L., Roychoudhury P., Xie H., Casto A., Cent A., Pepper G.,
RA   Koelle D.M., Huang M.L., Wald A., Johnston C., Jerome K.R.;
RT   "Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from
RT   Clinical Samples Reveals Extraordinarily Limited Evolution in Cell
RT   Culture.";
RL   MSphere 3:e00283-e00218(2018).
RN   [17] {ECO:0000313|EMBL:QAU09323.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=K47 {ECO:0000313|EMBL:QAU09323.1};
RA   Renner D.W., Bowen C.D., Umene K., Szpara M.;
RT   "Genome sequence of two predominant genotypes of herpes simplex virus 1
RT   from Japan.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GU734772; ADD60121.1; -; Genomic_DNA.
DR   EMBL; HM585512; ADM23590.1; -; Genomic_DNA.
DR   EMBL; HM585513; ADM23665.1; -; Genomic_DNA.
DR   EMBL; HM585515; ADM23816.1; -; Genomic_DNA.
DR   EMBL; JN420339; AER37845.1; -; Genomic_DNA.
DR   EMBL; JQ673480; AFE62879.1; -; Genomic_DNA.
DR   EMBL; JQ780693; AFI23642.1; -; Genomic_DNA.
DR   EMBL; KF498959; AGZ01913.1; -; Genomic_DNA.
DR   EMBL; KM222721; AJE59996.1; -; Genomic_DNA.
DR   EMBL; KM222722; AJE60067.1; -; Genomic_DNA.
DR   EMBL; KM222723; AJE60138.1; -; Genomic_DNA.
DR   EMBL; KM222726; AJE60352.1; -; Genomic_DNA.
DR   EMBL; KM222727; AJE60425.1; -; Genomic_DNA.
DR   EMBL; KT425110; ALM22842.1; -; Genomic_DNA.
DR   EMBL; KT899744; ALO18648.1; -; Genomic_DNA.
DR   EMBL; KT887224; ALO18724.1; -; Genomic_DNA.
DR   EMBL; MH160369; AWO70126.1; -; Genomic_DNA.
DR   EMBL; MH160370; AWO70220.1; -; Genomic_DNA.
DR   EMBL; MH160379; AWO71063.1; -; Genomic_DNA.
DR   EMBL; MH160380; AWO71152.1; -; Genomic_DNA.
DR   EMBL; MG999838; AWW07818.1; -; Genomic_DNA.
DR   EMBL; MG999843; AWW08330.1; -; Genomic_DNA.
DR   EMBL; MG999844; AWW08420.1; -; Genomic_DNA.
DR   EMBL; MG999847; AWW08718.1; -; Genomic_DNA.
DR   EMBL; MG999852; AWW09141.1; -; Genomic_DNA.
DR   EMBL; MG999858; AWW09704.1; -; Genomic_DNA.
DR   EMBL; MG999863; AWW10156.1; -; Genomic_DNA.
DR   EMBL; MG999867; AWW10515.1; -; Genomic_DNA.
DR   EMBL; MG999869; AWW10684.1; -; Genomic_DNA.
DR   EMBL; MG999874; AWW11178.1; -; Genomic_DNA.
DR   EMBL; MG999876; AWW11353.1; -; Genomic_DNA.
DR   EMBL; MG999879; AWW11625.1; -; Genomic_DNA.
DR   EMBL; MG999884; AWW12078.1; -; Genomic_DNA.
DR   EMBL; MG999886; AWW12244.1; -; Genomic_DNA.
DR   EMBL; MG999887; AWW12335.1; -; Genomic_DNA.
DR   EMBL; MG999889; AWW12497.1; -; Genomic_DNA.
DR   EMBL; MG999892; AWW12784.1; -; Genomic_DNA.
DR   EMBL; MG999893; AWW12876.1; -; Genomic_DNA.
DR   EMBL; MG999896; AWW13154.1; -; Genomic_DNA.
DR   EMBL; MG708284; AWX34687.1; -; Genomic_DNA.
DR   EMBL; MG708285; AWX34755.1; -; Genomic_DNA.
DR   EMBL; MG708286; AWX34826.1; -; Genomic_DNA.
DR   EMBL; MG708287; AWX34895.1; -; Genomic_DNA.
DR   EMBL; MG708288; AWX34965.1; -; Genomic_DNA.
DR   EMBL; MG708289; AWX35037.1; -; Genomic_DNA.
DR   EMBL; MG708290; AWX35106.1; -; Genomic_DNA.
DR   EMBL; MG708291; AWX35178.1; -; Genomic_DNA.
DR   EMBL; MG708292; AWX35248.1; -; Genomic_DNA.
DR   EMBL; MH999838; QAU09323.1; -; Genomic_DNA.
DR   EMBL; LT594107; SBS69483.1; -; Genomic_DNA.
DR   Proteomes; UP000107500; Genome.
DR   Proteomes; UP000110586; Genome.
DR   Proteomes; UP000126435; Genome.
DR   Proteomes; UP000131150; Genome.
DR   Proteomes; UP000180950; Genome.
DR   Proteomes; UP000180972; Genome.
DR   Proteomes; UP000271107; Genome.
DR   GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046080; P:dUTP metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.70.40.10; -; 2.
DR   HAMAP; MF_04031; HSV_DUT; 1.
DR   InterPro; IPR029054; dUTPase-like.
DR   InterPro; IPR036157; dUTPase-like_sf.
DR   InterPro; IPR034745; HSV_DUT.
DR   Pfam; PF00692; dUTPase; 1.
DR   SUPFAM; SSF51283; dUTPase-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ADM23590.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          207..336
FT                   /note="dUTPase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00692"
FT   REGION          350..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  39126 MW;  E620533B91C208A6 CRC64;
     MSQWGSGAIL VQPDSLGRGY DGDWHTAVAT RGGGVVQLNL VNRRAVAFMP KVSGDSGWAV
     GRVSLDLRMA MPADFCAIIH APALSSPGHH VILGLIDSGY RGTVMAVVVA PKRTREFAPG
     TLRVDVTFLD ILATPPALTE PISLRQFPQL APPPPTGAGI RADPWLEGAL GDPSVTPALP
     ARRRGRSLVY AGELTPVQTE HGDGVREAIA FLPKREEDAG FDIVVRRPVT VPANGTTVVQ
     PSLRMLHADA GPAACYVLGR SSLNARGLLV VPTRWLPGHV CAFVVYNLTG VPVTLEAGAK
     VAQLLVAGAD ALPWIPPDNF HGTKALRNYP RGVPDSTAEP RNPPLLVFTN EFDAEAPPSE
     RGTGGFGSTG I
//

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