ID D3YTV3_MOUSE Unreviewed; 1145 AA.
AC D3YTV3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=DEAH (Asp-Glu-Ala-His) box polypeptide 34 {ECO:0000313|Ensembl:ENSMUSP00000112865.2};
GN Name=Dhx34 {ECO:0000313|Ensembl:ENSMUSP00000112865.2,
GN ECO:0000313|MGI:MGI:1918973};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112865.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000112865.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112865.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000112865.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112865.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR ProteomicsDB; 335056; -.
DR Antibodypedia; 31552; 87 antibodies from 16 providers.
DR Ensembl; ENSMUST00000118795.8; ENSMUSP00000112865.2; ENSMUSG00000006019.16.
DR Ensembl; ENSMUST00000119102.8; ENSMUSP00000113393.2; ENSMUSG00000006019.16.
DR Ensembl; ENSMUST00000121123.8; ENSMUSP00000113673.2; ENSMUSG00000006019.16.
DR AGR; MGI:1918973; -.
DR MGI; MGI:1918973; Dhx34.
DR VEuPathDB; HostDB:ENSMUSG00000006019; -.
DR GeneTree; ENSGT00940000158721; -.
DR TreeFam; TF313217; -.
DR ChiTaRS; Dhx34; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000006019; Expressed in dorsal pancreas and 193 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:2000623; P:negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:Ensembl.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR CDD; cd17979; DEXHc_DHX34; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF148; ATP-DEPENDENT RNA HELICASE DHX34-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:D3YTV3,
KW ECO:0007829|MaxQB:D3YTV3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 174..334
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 370..538
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 128624 MW; A7F321BC2006D4C0 CRC64;
MPPPRTREGR GHRDRDHHRA PREEEAPEKW DWNCPETRCL LEDVFFRDED YIRRGSEECQ
KFWAFFERLQ RFQHLKTSQK KEKDPGMPKH GIAALADLPL TYDPRYRINL SILSPDTRGR
HGPGRGLPPE RVSEFRRALL HYLDFQQKQA FGRLVKLQRE RAALPIAQYG NRILQTLKEH
QVVVVAGDTG CGKSTQVPQY LLAAGFSHVA CTQPRRIACI SLAKRVGFES LSQYGSQVGY
QIRFESTRSA ATKIVFLTVG LLLRQIQREP SLPQYQVLIV DEVHERHLHN DFLLGVLQRL
LPQRPDLKVI LMSATINISL FSSYFSHAPV VQVPGRLFPI TVVYQPQEAD QTASKSEKLD
PRPFLRVLEA IDNKYPPEER GDLLVFLSGM AEITTVLDAA QAYASLTQRW VVLPLHSALS
VSDQDKVFDV APAGVRKCIL STNIAETSVT IDGIRFVVDS GKVKEMSYDP QAKLQRLQEF
WISQASAEQR KGRAGRTGPG VCYRLYAESD YDAFAPYPVP EIRRVALDAL VLQMKSMSVG
DPRTFPFIEP PPPASVETAI LYLQEQGALD SSEALTPIGS LLAQLPVDVV IGKMLILGSM
FSLAEPVLTI AAALSVQSPF TRSAQSNLDC ATARRPLESD QGDPFTLFNV FNAWVQVKSE
RSGNSRKWCR RRGVEEHRLY EMANLRRQFK ELLEDHGLLS GAQVVAPGDS YSRLQQRRER
RALHQLKRQH EEGGGRRRKV LRLQEDGCSS DEEDREGSTS QRADSVDIQD VKFKLRHNLE
QLQAAASSAQ DLTRDQLALL KLVLGRGLYP QLAVPDAFNS GRKDSDQIFH TQAKQGTVLH
PTCVFANSPE VLHTQGQEAS GQEGSQDGRD QMSCKHQLLA FVSLLETNKP YLVNCVRIPA
LQSLLLFSRS IDTNGDCSRL VADGWLELQL ADSESAVRLL ATSLRLRVHW ESALDRQLAR
QAQRRKLEQE EDMGSPAVSP QEVAALSREL LQFMVAKVPY RLRRLTGLEA QNLYVGPQTI
TTAPSLPGLF GNSTLSPHPT KGGYAVSDYL TYNCLTSDTD LYSDCLRSFW TCPHCGLHMP
FTPLERIAHE NTCPEAPGDD PGKSEAAPAP PQKTSALQRP YHCQVCGQDF LFTPTEVLRH
RRQHV
//
