ID D3YW96_MOUSE Unreviewed; 379 AA.
AC D3YW96;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=SPRY domain-containing SOCS box protein 3 {ECO:0000256|ARBA:ARBA00014684};
GN Name=Spsb3 {ECO:0000313|Ensembl:ENSMUSP00000112589.2,
GN ECO:0000313|MGI:MGI:1891471};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112589.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000112589.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112589.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000112589.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112589.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC complex which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000256|ARBA:ARBA00004094}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SPSB family.
CC {ECO:0000256|ARBA:ARBA00010910}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006525233.1; XM_006525170.3.
DR RefSeq; XP_011245035.1; XM_011246733.2.
DR AlphaFoldDB; D3YW96; -.
DR ProteomicsDB; 303656; -.
DR Antibodypedia; 23246; 36 antibodies from 17 providers.
DR Ensembl; ENSMUST00000119829.8; ENSMUSP00000112589.2; ENSMUSG00000024160.18.
DR GeneID; 79043; -.
DR AGR; MGI:1891471; -.
DR CTD; 90864; -.
DR MGI; MGI:1891471; Spsb3.
DR VEuPathDB; HostDB:ENSMUSG00000024160; -.
DR GeneTree; ENSGT01030000234629; -.
DR OrthoDB; 4057255at2759; -.
DR PhylomeDB; D3YW96; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 79043; 3 hits in 63 CRISPR screens.
DR ChiTaRS; Spsb3; mouse.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000024160; Expressed in ear vesicle and 246 other cell types or tissues.
DR ExpressionAtlas; D3YW96; baseline and differential.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12876; SPRY_SOCS3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035754; SPRY_SPSB3.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR PANTHER; PTHR12245:SF5; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 85..299
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 301..334
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 32..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 42141 MW; 7ED39690F26C518D CRC64;
MARRTRSSRA WHFVLSAARR DTDARAVALA GSSNWGYDSD GQHSDSDSDP EYSSLPPSIP
SAVPVTGESF CDCEGQNEAT FCNSLHTAHR GKDCRCGEED EDFDWVWDDL NKSSATLLSC
DNRKVSFHME YSCGTAAIRG TKELGDGQHF WEIKMTSPVY GTDMMVGIGT SDVDLDKYHH
TFCSLLGRDE DSWGLSYTGR CCLGHGWGWQ YSRPPRITPL LLAGLLHHKG DKTSFSSRFG
QGSIIGVHLD TWHGTLTFFK NRKCIGVAAT RLQNRRFYPM VCSTAAKSSM KVIRSCASST
SLQYLCCYRL RQLRPNSGDT LEGLPLPPGL KQVLHNKLGW VLSMNCNHWK SPVPPPGTAT
PGAESLETRP CQRKRCRRS
//
