ID D3YY08_MOUSE Unreviewed; 1129 AA.
AC D3YY08;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Tubulin tyrosine ligase-like family, member 4 {ECO:0000313|Ensembl:ENSMUSP00000109308.2};
GN Name=Ttll4 {ECO:0000313|Ensembl:ENSMUSP00000109308.2,
GN ECO:0000313|MGI:MGI:1914784};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000109308.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000109308.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109308.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000109308.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109308.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR AlphaFoldDB; D3YY08; -.
DR SMR; D3YY08; -.
DR MaxQB; D3YY08; -.
DR PeptideAtlas; D3YY08; -.
DR ProteomicsDB; 355259; -.
DR Antibodypedia; 34286; 135 antibodies from 24 providers.
DR Ensembl; ENSMUST00000113678.2; ENSMUSP00000109308.2; ENSMUSG00000033257.15.
DR AGR; MGI:1914784; -.
DR MGI; MGI:1914784; Ttll4.
DR VEuPathDB; HostDB:ENSMUSG00000033257; -.
DR GeneTree; ENSGT00940000157916; -.
DR ChiTaRS; Ttll4; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000033257; Expressed in dorsal pancreas and 224 other cell types or tissues.
DR ExpressionAtlas; D3YY08; baseline and differential.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IEA:UniProt.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241:SF162; TUBULIN MONOGLUTAMYLASE TTLL4; 1.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:D3YY08,
KW ECO:0007829|PeptideAtlas:D3YY08};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..531
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 124793 MW; C38CFDC2BEFC03D5 CRC64;
MASAGTEHYS IGLRRGNSFK QRHPSGTVSA SPSEKPSEVK VWSQAHQQVK PIWKLEKKHV
GTLSAGLGTS FLGVPSQPAY FLCPSTLCSS GTTAVIAGHS NPCYLQSLPN LFSNTLLYRR
TNVRQKPYQQ LESFCLRSSP SEKRSFSLPQ KGLPVSVTAN KATSSTVFPM AQPMATSPTD
PYLSLAAAGE NPSRKSLASA ISGKIASPLS YKPMLNNNSF MRPNSTKVPL SQATDGLKPV
SSPKIQPVSW HHSGGTGDCV PQPGDHKVPQ NIATVLDDVT APITPSIPST LNISTASVTS
SQCSQSNFRM EAHPCGLDEN PDSQSATKEV HFTEAVRKLA EKGLEKMPRQ GYQFEQACFV
NPSFQWGLLN RSRRWKPLMG QRFPQEDIGL DSAILPGTSD TLGLDSTVFC TKRISIHLLA
SHVHGLNPSP ACGSAVDPQV LGEDRAPVPP SSLQPLGVAE VATRLSSVHL DQPGKEPEEA
KDLNSCTKGG GSATDLQPNQ VEPEDTEDEL GDGLEDSCSH DENEEEEGDS ECSSLSVVSP
SESVALISRN CVDLMSKSLP NHEKVVRPAL IYSLFPNVTP TIYFGTRDER VEKLPWEQRR
LLRWKMSTVT PNIVKQTIGR SHFKISKRND DWLGCWGHHM KSPGFRSIRE HQKPASARGI
GIQVIHKWSQ LPKRRPLLVQ RYLHKPYLIS GSKFDLRIYV YVTSYDPLRI YLFSDGLVRF
ASCKYSPSMK SLSNKFMHLT NYSVNKKNTE YQANADETAC QGHKWALKAL WNYLSQKGIN
SDAIWEKIKD VVVKTIISSE PYVTNLLKLY VRRPYSCHEL FGFDIMLDEN LKPWVLEVNI
SPSLHSNSPL DISIKGQMIR DLLNLAGFVL PNMEDIISSS SSPSSSSGSS TSLPSSPRDK
CQMTPEHFTA QKMKKAYYLT QKIPDQDFYA SVLDVLTPDD VRVLVEMEDE FSRRGQFERI
FPSRISSRYL RFFEQPRYFN ILTTQWEQKY HGNKLKGVDL LRNWCYKGFH TGIVSDSAPL
WSLPTSLMTT SKGDGTPNSA SKSRKKSASE GTTLSSEDRS TPKSKKSQAG LSPISRKTLS
SRSNENTSKQ SKRSTPGLPV LKYSGQSSRL SAASASQSVT DSRLTAVSS
//
