ID D3YY99_MOUSE Unreviewed; 205 AA.
AC D3YY99;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Pleckstrin homology domain containing, family G (with RhoGef domain) member 2 {ECO:0000313|Ensembl:ENSMUSP00000118217.2};
DE Flags: Fragment;
GN Name=Plekhg2 {ECO:0000313|Ensembl:ENSMUSP00000118217.2,
GN ECO:0000313|MGI:MGI:2141874};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118217.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000118217.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118217.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000118217.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118217.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; D3YY99; -.
DR SMR; D3YY99; -.
DR MaxQB; D3YY99; -.
DR ProteomicsDB; 318936; -.
DR Antibodypedia; 30324; 67 antibodies from 14 providers.
DR Ensembl; ENSMUST00000147362.8; ENSMUSP00000118217.2; ENSMUSG00000037552.18.
DR AGR; MGI:2141874; -.
DR MGI; MGI:2141874; Plekhg2.
DR VEuPathDB; HostDB:ENSMUSG00000037552; -.
DR GeneTree; ENSGT00940000162093; -.
DR HOGENOM; CLU_1380911_0_0_1; -.
DR ChiTaRS; Plekhg2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000037552; Expressed in internal carotid artery and 203 other cell types or tissues.
DR ExpressionAtlas; D3YY99; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|ProteomicsDB:D3YY99};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 99..205
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 36..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 205
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000118217.2"
SQ SEQUENCE 205 AA; 21868 MW; FC3D0FF0668C9708 CRC64;
MPEGARGLSL PKPSLRLGCG HQGEVCDCAA VSDTPTAAQA ATTMASPRGS GSSTSLSTVG
SEGDPSPACS ASRPEPLPEP PIRLHLLPVG IQGSVKPSRL ERVAREIVET ERAYVRDLRS
IVEDYLGPLM DGRALGLNME QVGTLFANIE DIYEFSSELL EDLEGCSSAG GIAECFVQRS
EDFDIYTLYC MNYPSSLALL RELSV
//
