ID D3YZ97_MOUSE Unreviewed; 567 AA.
AC D3YZ97;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Vomeronasal 2, receptor 42 {ECO:0000313|Ensembl:ENSMUSP00000123451.2};
GN Name=Vmn2r42 {ECO:0000313|Ensembl:ENSMUSP00000123451.2,
GN ECO:0000313|MGI:MGI:1316666};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123451.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123451.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123451.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123451.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123451.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR AlphaFoldDB; D3YZ97; -.
DR SMR; D3YZ97; -.
DR Ensembl; ENSMUST00000142934.3; ENSMUSP00000123451.2; ENSMUSG00000070844.12.
DR AGR; MGI:1316666; -.
DR MGI; MGI:1316666; Vmn2r42.
DR VEuPathDB; HostDB:ENSMUSG00000070844; -.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_2_3_1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000070844; Expressed in blastoderm cell in morula and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF436; EC2-V2R PHEROMONE RECEPTOR PROTEIN-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..567
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003053135"
FT DOMAIN 76..467
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT DOMAIN 511..559
FT /note="GPCR family 3 nine cysteines"
FT /evidence="ECO:0000259|Pfam:PF07562"
SQ SEQUENCE 567 AA; 65473 MW; B9808D0CF833C3AC CRC64;
MFIFMGVFFL LNITLLMANF IDPRCFWRIN LDEITDEYLG LSCAFILAAV QTPIEKDYFN
TTLNFLKTTK NHKYALALVF AMDEINRYPD LLPNMSLIIR YSLGHCDGKT VTPTPYLFHR
KKQSPIPNYF CNEESMCSFL LSGPNWDESL SFWKYLDSFL SPRILQLSYG SFSSIFSDDE
QYPYLYQMAP KDTSLALAMV SFILYLKWNW IGLVIPDDDQ GNQFLLELKK QSENKEICFA
FVKMISVDEV SFPQKTEINY KQIVKSLTNV IIIYGETYNF IDLIFRMWEP PILQRIWITT
KQLNFPTSKT DISHDTFYGS LTFLPHHGEI SGFKNFVQTW FHLRNTDLCL VMPEWKYINS
EDSASNCKIL KNSSSDASFD WLMEEKLDMA FSENSHNIYN AVHAIAHALH EMNLQQADNQ
AIDNGKGASS HCLKVNSFLR RTYFTNPLGD KVFMKQRVIM QDEYDIVHFA NLSQHLGIKM
KLGKFSPYLP HGRHSHLYVD MIELATGRRK MPSSVCSADC SPGFRRLWKE GMAACCFVCS
PCPENEISNE TSSSPFHPCI KTGTFMG
//
