ID D3Z1T0_MOUSE Unreviewed; 215 AA.
AC D3Z1T0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=AlkB homolog 6 {ECO:0000313|Ensembl:ENSMUSP00000121953.2};
DE Flags: Fragment;
GN Name=Alkbh6 {ECO:0000313|Ensembl:ENSMUSP00000121953.2,
GN ECO:0000313|MGI:MGI:2142037};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000121953.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000121953.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121953.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000121953.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121953.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the alkB family.
CC {ECO:0000256|ARBA:ARBA00007879}.
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DR AlphaFoldDB; D3Z1T0; -.
DR SMR; D3Z1T0; -.
DR ProteomicsDB; 355348; -.
DR Antibodypedia; 68413; 81 antibodies from 17 providers.
DR Ensembl; ENSMUST00000136887.8; ENSMUSP00000121953.2; ENSMUSG00000042831.14.
DR AGR; MGI:2142037; -.
DR MGI; MGI:2142037; Alkbh6.
DR VEuPathDB; HostDB:ENSMUSG00000042831; -.
DR GeneTree; ENSGT00510000048626; -.
DR HOGENOM; CLU_059836_2_0_1; -.
DR ChiTaRS; Alkbh6; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000042831; Expressed in adrenal gland and 63 other cell types or tissues.
DR ExpressionAtlas; D3Z1T0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032862; ALKBH6.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR46030; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR PANTHER; PTHR46030:SF1; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 1: Evidence at protein level;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|EPD:D3Z1T0,
KW ECO:0007829|MaxQB:D3Z1T0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 82..213
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT NON_TER 215
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000121953.2"
SQ SEQUENCE 215 AA; 24189 MW; F3195D0F53374932 CRC64;
MEEQDARVPA LEPFRVEQEE EEYLLRQVFN APKPKWTQLS GRKLQNWGGL PHPRGMVPER
LPPWLQRYVD KVSDLSLFGG LPANHVLVNQ YLPGEGIMPH EDGPLYYPTV STISLGSHTV
LDFYEPRQPD DDVPMEQPRP PQRPITSLLV EPRSLLVLRG TAYTRLLHGI SATRVDELDA
TSLPPNATAC KSALPGAHLV RGTRVSLTIR RVPRV
//
