ID D3ZA00_RAT Unreviewed; 336 AA.
AC D3ZA00;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=ATPase H+ transporting accessory protein 1 like {ECO:0000313|Ensembl:ENSRNOP00000050073.3};
GN Name=Atp6ap1l {ECO:0000313|Ensembl:ENSRNOP00000050073.3,
GN ECO:0000313|RGD:1564936};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000050073.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000050073.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050073.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000050073.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000050073.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the vacuolar ATPase subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00009037}.
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DR RefSeq; NP_001178772.1; NM_001191843.1.
DR AlphaFoldDB; D3ZA00; -.
DR SMR; D3ZA00; -.
DR STRING; 10116.ENSRNOP00000050073; -.
DR PaxDb; 10116-ENSRNOP00000050073; -.
DR Ensembl; ENSRNOT00000044237.5; ENSRNOP00000050073.3; ENSRNOG00000040201.4.
DR GeneID; 361875; -.
DR KEGG; rno:361875; -.
DR UCSC; RGD:1564936; rat.
DR AGR; RGD:1564936; -.
DR CTD; 92270; -.
DR RGD; 1564936; Atp6ap1l.
DR eggNOG; KOG3868; Eukaryota.
DR GeneTree; ENSGT00940000158156; -.
DR HOGENOM; CLU_071317_0_0_1; -.
DR InParanoid; D3ZA00; -.
DR OMA; SRKGQWE; -.
DR OrthoDB; 2878970at2759; -.
DR PhylomeDB; D3ZA00; -.
DR TreeFam; TF325819; -.
DR PRO; PR:D3ZA00; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000040201; Expressed in testis and 9 other cell types or tissues.
DR Genevisible; D3ZA00; RN.
DR GO; GO:0033176; C:proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0030641; P:regulation of cellular pH; IBA:GO_Central.
DR Gene3D; 2.40.160.110; -; 1.
DR InterPro; IPR008388; Ac45_acc_su.
DR InterPro; IPR046756; VAS1/VOA1_TM.
DR InterPro; IPR046755; VAS1_LD.
DR PANTHER; PTHR12471:SF3; V-TYPE PROTON ATPASE SUBUNIT S1-LIKE PROTEIN; 1.
DR PANTHER; PTHR12471; VACUOLAR ATP SYNTHASE SUBUNIT S1; 1.
DR Pfam; PF20520; Ac45-VOA1_TM; 1.
DR Pfam; PF05827; VAS1_LD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..336
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003052503"
FT TRANSMEM 261..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..240
FT /note="V-type proton ATPase subunit S1 luminal"
FT /evidence="ECO:0000259|Pfam:PF05827"
FT DOMAIN 256..291
FT /note="V-type proton ATPase subunit S1/VOA1 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF20520"
FT REGION 37..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 37887 MW; 2659F5017B09E4A1 CRC64;
MGRKLLFSFS LLFLCMVFSV SLDQILARKN VGSQASSSKE AIVPNGQRNS GEVKPVQNLT
TVPITQTFNY NLSKAHWSTF SHHNPVKFSR DGIPCILFWT KRITVKFKNQ TWLDLTDEAL
GQNTTVDTGN SNCSEENAVL SLKFGDAENP KDIDIRFTLS NYIKLSSQSW FSLHRVEIIF
NNSVQATFNA TGIYALSTYS YHCQRVSSLR RNDALLLLSS SDDVTSLWEV TFIDFQIQGF
SIKGAQFSQA RDCSSSFSPA VLIGLAMSLI LLLVLAYALH MLIYLRYLDH HYEFITSPAH
FPSLRALDIG EEKELLGSQG AECYELRNQQ ICKIYI
//
