ID D3ZCH1_RAT Unreviewed; 2047 AA.
AC D3ZCH1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Ankyrin repeat domain 12 {ECO:0000313|Ensembl:ENSRNOP00000017613.4};
GN Name=Ankrd12 {ECO:0000313|Ensembl:ENSRNOP00000017613.4,
GN ECO:0000313|RGD:1310118};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000017613.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000017613.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017613.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000017613.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017613.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001101708.1; NM_001108238.1.
DR AlphaFoldDB; D3ZCH1; -.
DR SMR; D3ZCH1; -.
DR STRING; 10116.ENSRNOP00000017613; -.
DR PhosphoSitePlus; D3ZCH1; -.
DR PaxDb; 10116-ENSRNOP00000017613; -.
DR Ensembl; ENSRNOT00000017613.7; ENSRNOP00000017613.4; ENSRNOG00000012733.8.
DR GeneID; 316775; -.
DR KEGG; rno:316775; -.
DR AGR; RGD:1310118; -.
DR CTD; 23253; -.
DR RGD; 1310118; Ankrd12.
DR eggNOG; ENOG502QQG5; Eukaryota.
DR GeneTree; ENSGT00940000154742; -.
DR HOGENOM; CLU_001632_0_0_1; -.
DR OMA; PQVHHPR; -.
DR OrthoDB; 4556913at2759; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000012733; Expressed in lung and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24149; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR24149:SF16; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 2047 AA; 233253 MW; 22D7BB6540D4555F CRC64;
MPKSGFTKPV QSENSDSDSS MVERPYGRKS KDKIASYSKT SKIDRGDMGK EIREKSSMKR
KLPFTLSPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TRKEAGTKKS
TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPSHPSQA TPAQKKTPSS SSRQKDKINK
RNERGETPLH MAAIRGDVKQ VKELISLGAD VNVKDFAGWT PLHEACNVGY YDVAKILIAA
GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
KREVPLSGDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSF VCGSQSLPSK APLPSALDEY
EFKDDDGEEI SKMIDGRHIL RREQRKENES EAERSGLFAK QEKPFYSKSF KTKKQKPSRV
LYSSTESSDE EVLQNRKIST ACSVAETSHS DVQAKREYEY KQKGKVKRKL KNQNKNKENQ
ELKQEKEGKE NSRIANLAVN TALDCSERNR EDGAFRRSFS PKDDASLHLL HMPTGKSPKH
PCGLSEKQAT PLKQDHMKTC ISPGSSETSL QPELSRYENA EPEFLPESSN VKPYKHKEKN
KHQKDFHLEF GEKSNAKIKD EDHSAAFENS DCTLKKMDKE GKTLKKHKLK HKERDKEKHR
KEAEGEKEKY KSRDNAKEPQ RSIEFDREFW KENFFKSDET EDLFLNMEHE SLTEKKSKVE
KTVKDDRLAK DKHASKERNC KEEREKTKRE NEKSLKEERL KDPKEEKDGV SAEKEAEGSS
MAVSANQETS GPHSSEREVD IEKQERHSKE REKSDRRFQT KEKELDRTER KVSEKEKKLK
HEHKSEREKL DFSDCTDRVK EKDRLYSPQT ERCHKEGEKM RNTVRKAEDR ERAREKTDRK
HDREKPERER CLAESKEKYL EKRKQSDNSE YSKSEKVRNR DRDREGEKKE KLRDKESVNV
ANLRHLQEER KSSTGEGSSK TQHEKALSLK ERVRDEPLKI PDGKEKDKKD IDRYKERDKR
KEKAQLSTLI RLKSETEKLK PKLSPASKDA RPKEKRLVND DLMQTSFERM LSLKDLEIEQ
WHKKHKEKIK QKEKERLRNR SCLELKVKDK EKTKHTPSES KNKELTRSRS SELTDVYNKE
KQSKDVGSNR SQSVDNKSVL SLGKLPYVSE NSSSRSPRSE GEKLGLSSRS VSMLSVASSE
DSCHTVTTPR PLVEYDSDFM LEGSESQLSF SQSPFLPNAK SPALYERELE SLAELPERLK
PPYANRLPVC HLRSSSVEDV KLITNEVRPA VEIRRCSMPS VICEPIKHFQ VSEDSSQGNL
AVPRETSLSP RPEVSLVPER GLSHVSDLHP RCTDSPVRSV DSSSVSSDVH VIKSAALVGT
LIDTSMHLET SNQVGVIQSK SWETPVDKLE SLSTNDFICP DSSTSDQDSS AQSFYHSENK
MLREQNADCL PVHQTELPGN SCAQDPASFT LSSPQPCSFT NQSLSDAESL PKPVSLSYGA
SQEPGVLQQR SAAHMISSVL ESDNNFTKEV ESSFVLADIQ KTNSFVPAYS ESTVQETLPN
FEKANTLLVL PSEKDFSGSD AASQLNTHYA FSKLTYKSSS SHEIEKGPDD TQVISHEKEN
KLQSLVLTPL SKCDSDLYEV NAGMPKGNLN EQDNPKHGPD SEKDSLSTED EESQQSTLSS
VENHSQQSAQ PEIQKYDQMV KGELEENAED DKTENQTPQR MTRNKASALV SQSKQVLAGC
TLLPEKDNDS SPRGRIRLTE EDDPQIHHPR KRKVSRVPQP VQVSPSLLQA KEKTQQSLAA
LVDSLKLDEI EPYSSERANP YFEYLHIRKK IEEKRKLLCS VIPQAPQYYD EYVTFNGSYL
LDGNPLSKIC IPTITPPPSL SDPLKELFRQ QEVVRMKLRL QHSIEREKLI VSNEQEVLRV
HYRAARTLAN QTLPFSACTV LLDAEVYNVP LDSQSDDSKT SVRDRFNARQ FMSWLQDVDD
KFDKLKTCLL MRQQHEAAAL NAVQRLEWQL KLQELDPATY KSISIYEIQE FYVPLVDVND
DFELTPI
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