ID D3ZHR4_RAT Unreviewed; 939 AA.
AC D3ZHR4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Ankyrin repeat domain 35 {ECO:0000313|Ensembl:ENSRNOP00000053068.4};
GN Name=Ankrd35 {ECO:0000313|Ensembl:ENSRNOP00000053068.4,
GN ECO:0000313|RGD:1305527};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000053068.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000053068.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000053068.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000053068.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000053068.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006224285.1; XM_006224223.3.
DR RefSeq; XP_006233058.1; XM_006232996.3.
DR AlphaFoldDB; D3ZHR4; -.
DR STRING; 10116.ENSRNOP00000053068; -.
DR PhosphoSitePlus; D3ZHR4; -.
DR PaxDb; 10116-ENSRNOP00000053068; -.
DR Ensembl; ENSRNOT00000056225.5; ENSRNOP00000053068.4; ENSRNOG00000025108.7.
DR GeneID; 365881; -.
DR KEGG; rno:365881; -.
DR AGR; RGD:1305527; -.
DR CTD; 148741; -.
DR RGD; 1305527; Ankrd35.
DR VEuPathDB; HostDB:ENSRNOG00000025108; -.
DR eggNOG; ENOG502QXWS; Eukaryota.
DR GeneTree; ENSGT00530000063074; -.
DR HOGENOM; CLU_298955_0_0_1; -.
DR InParanoid; D3ZHR4; -.
DR OMA; HGANEDC; -.
DR OrthoDB; 5477337at2759; -.
DR TreeFam; TF331274; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000025108; Expressed in testis and 9 other cell types or tissues.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF85; LD20463P-RELATED; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 7..34
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 35..67
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 68..100
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 101..133
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 134..166
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 196..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 549..590
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 718..745
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 862..896
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 939 AA; 103525 MW; D6D28E5C512D994A CRC64;
MASPRKFHLA ASKGLTECLT ILLANGADIN SKNEDGSTAL HLATISCQPQ CVKVLLQHGA
NEDAVDAENR SPLHWAASSG CASSVLLLCD HEAFLDVLDN DGRTPLMIAS LGGHAAICSQ
LLQRGARVNV TDKDDKSALI LACEKGSAEV AELLLSHGAD AGAVDSLGHN ALHYALGTQD
RELWRLLQQA LNRRRRGGRE LVQHPDHASQ ASSSESPWRA EPEEEQEEEK GEERGSEEWR
WKFEEEQRKV HQLEQELLQK TDECKARAAA FVSLENQIRE QVQELGYLLV QVPGAPRNQG
PGLRPEGDGM EQGCPLNLLA EWIQELKKQQ KATATINPTL VPKRAEDLAP AETHYEVPGK
FQPEQGLSQS PRSETIGKAT GQQLNTNGEQ NLDLDNTEQV CADQKERALA PGTEPAVTVG
EPVGIAAMNQ LLLQLREELA AVWREKDAAR GALSRPVLEG ALGTPRAEAA AAAWEKMEAR
LEKVLVRLDG AKMGLHVKPE VPAQGSRDGA PKIVQGCTKE QEGKRAPGAR GEPLGAPGGE
QALGGGLAKG QLEKEVSALR LSNSNLLEEL EELGRERQRL QGELQSLTQK LQREFVPKPE
AQVQLQQLRR SVGLLTEELA IEKEATEKLR RRLASQTSGL QGLWNCFPPD LVGKGSARST
AAEPLEELQA CISTLVDRHL ESQQVQARLE EENQRLRGSL PPCGEPEASL KATASPQVAA
LEEDLGKLEE ELRAVQATMS GKSQEICKLK QLLYQATEEV AELRAREAAS LRQHEKTRGS
LVAQAQAWGQ ELKVMLEKYN TACREMTRLR DTAAEERRRS EELAARAAEQ ERQAGEMRGR
SEQFEKTAEL LKEKTNHLIG ACRDKESKIK ELLKKLEQLS EEVLEVRAEN THLVLQLQDT
QKNHEEIIST YRNHLLNAAR GYMEQDVYNI LLRILSVQE
//
