ID D3ZJU0_RAT Unreviewed; 1826 AA.
AC D3ZJU0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=AT-rich interaction domain 2 {ECO:0000313|Ensembl:ENSRNOP00000006970.6};
GN Name=Arid2 {ECO:0000313|Ensembl:ENSRNOP00000006970.6,
GN ECO:0000313|RGD:1311105};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000006970.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000006970.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006970.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000006970.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000006970.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_345868.4; XM_345867.8.
DR AlphaFoldDB; D3ZJU0; -.
DR STRING; 10116.ENSRNOP00000006970; -.
DR iPTMnet; D3ZJU0; -.
DR PhosphoSitePlus; D3ZJU0; -.
DR PaxDb; 10116-ENSRNOP00000006970; -.
DR PeptideAtlas; D3ZJU0; -.
DR Ensembl; ENSRNOT00000006970.9; ENSRNOP00000006970.6; ENSRNOG00000004831.9.
DR GeneID; 366980; -.
DR KEGG; rno:366980; -.
DR UCSC; RGD:1311105; rat.
DR AGR; RGD:1311105; -.
DR CTD; 196528; -.
DR RGD; 1311105; Arid2.
DR eggNOG; KOG2312; Eukaryota.
DR GeneTree; ENSGT00390000016138; -.
DR HOGENOM; CLU_003714_0_0_1; -.
DR InParanoid; D3ZJU0; -.
DR OMA; NGQKCME; -.
DR OrthoDB; 5001776at2759; -.
DR TreeFam; TF106406; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000004831; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0016514; C:SWI/SNF complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; ISO:RGD.
DR GO; GO:0072359; P:circulatory system development; ISO:RGD.
DR GO; GO:0060982; P:coronary artery morphogenesis; ISO:RGD.
DR GO; GO:0048568; P:embryonic organ development; ISO:RGD.
DR GO; GO:0003007; P:heart morphogenesis; ISO:RGD.
DR GO; GO:0042592; P:homeostatic process; ISO:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0006337; P:nucleosome disassembly; ISO:RGD.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISO:RGD.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16866; ARID_ARID2; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR22970; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22970:SF14; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:D3ZJU0};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 13..105
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 524..603
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 823..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1478..1522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1593
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1826 AA; 195057 MW; 06404642A7876DBB CRC64;
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF
AKVSEKNQWG EIVEEFNFPR SCSNAAFALK QYYLRYLEKY EKVHHFGEDD DEVPPGNPKP
QLPIGAIPSS YNYQQHSVSD YLRQSYGLSM DFNSPNDYNK LVLSLLSGLP NEVDFAINVC
TLLSNESKHV MQLEKDPKII TLLLANAGVF DDTLGSFSTV FGEEWREKTD RDFVKFWKDI
VDDNEVRDLI SDRNKAHEDT PGEWIWESLF HPPRKLGIND IEGQRVLQIA VILRNLSFEE
SNVKLLAANR TCLRFLLLSA HSHFISLRQL GLDTLGNIAA ELLLDPVDFK TTHLMFHTVT
KCLMSRDRFL KMRGMEILGN LCKAEDNGVL ICEYVDQDSY REIICHLTLP DVLLVTSTLE
VLYMLTEMGD IACTKIAKVE KSIDMLVCLV SMDIQMFGPD ALAAVKLVEH PSSSHQVLSE
MRPQAIEQVQ TQSHGAPGPA CRAVVAQHAA PPPGIVEIDS EKFACQWLNA HFEVNPDCSV
SRAEMYSEYL STCSKLARGG ILTSTGFYKC LRTVFPNHTV KRVEDSSSSG QAHIHVIGVR
RRALPLPIQM YYQQQPVSTP VVRVDAVADV SPTPSPAGIP HGSQAVGNHF QRTPVTNQSS
NLTATQMSFP VQGVHTVAQT VSRIPPNPSV HTHQQQNSPV TVIQNKAPIP CEVVKATVIQ
NSVPQTAVPV SIAVGGPAQS SLAQNHSAGP QPVTVVNSQT LLHHPSVMPQ PSPLHTVVPG
QIPSGTPVTV IQQTVPQSHI FGRVQNIPAC TSTVSQGQQL ITTSPQPMHT SSQQTAAGSQ
PQDTVIIAPP QYVTTSASSI VSATSVQNFQ VATGQVVTIA GVPSPQPSRV GFQNIAPKPL
PSQHVSSTVV QQPVQQPQQP AQQSVVIVSQ PAQQGQTYAP AIHQIVLANP AALPTGQTVQ
LTGQPNITPS SSPSPVPATS NQVPAAMSSS STLQSQGPPP TVSQMLSVKR QQQQQHSPAA
PAQQVQVQVQ PPQVQVQVQP QQAGAGVGQP ASSESSLIKQ LLLPKRGPST PGGKLILPAP
QIPPPNNARA PSPQVVYQVA NSQAAGFGAQ GQTPAQQLLV GQPNVQLVQS AMPPTGGVQT
VPISNLQILP GPLISNSPAT IFQGTSGNQV TITVVPNTSF ATATVSQGNA AQLIAPAGIS
MSGAQAGAGL QVQTLPAGQS ACTSAAPPFK GDKIICQKEE EAKEATGLHV HERKIEVMEN
PSCRRGTTNT SNGDTSESET QVGSLLNGRK YSDSSLPPSH SGKLQSEPNP CSPLSNGPSL
ELGENGASGK QNSEPVDMQD VKSDLKKTLV NGICDFDKGD GSHLSKNIPN HKTCNHVGNG
EVSPVEPQGT LGATQQETAK GDQLERVPNG PALTLGGSPA TSSVQEASSV ATQPFSGTDL
PNGPLASGLT SDVPHQRPSV VVSPRPTAPV IQGHPVIAAP HSGSRGPASA LSSDARSTNG
TAECKTVKRP AEDGDREAAP GIPNKVGVRI VTISDPNNAG CSATMVAVPA GADPSTVAKV
AIGSAAQQKP PPPPAYAQSA LPQNTPMPPS PAVQVQGQPS SSQPSPVSAS SQHADPVRKP
GQNFMCLWQS CKKWFQTPSQ VFYHAATEHG GKDVYPGQCL WEGCEPFQRQ RFSFITHLQD
KHCSKDALLA GLKQDEPGQA ANQKSSTKQP TVGSTGSAPR AQKAIASHPS AALMALRRGS
RNLVFRDFTD EKEGPITKHI RLTAALILKN IGKYSECGRR LLKRHENNLS VLAISNMEAS
STLAKCLYEL NFTVQSKEQE QDSEML
//
