ID D3ZPJ1_RAT Unreviewed; 709 AA.
AC D3ZPJ1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Kelch-like family member 11 {ECO:0000313|Ensembl:ENSRNOP00000022695.3};
GN Name=Klhl11 {ECO:0000313|Ensembl:ENSRNOP00000022695.3,
GN ECO:0000313|RGD:1306673};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000022695.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000022695.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022695.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000022695.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022695.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001099308.1; NM_001105838.1.
DR AlphaFoldDB; D3ZPJ1; -.
DR SMR; D3ZPJ1; -.
DR STRING; 10116.ENSRNOP00000022695; -.
DR PhosphoSitePlus; D3ZPJ1; -.
DR PaxDb; 10116-ENSRNOP00000022695; -.
DR Ensembl; ENSRNOT00000022695.5; ENSRNOP00000022695.3; ENSRNOG00000016921.5.
DR GeneID; 287706; -.
DR KEGG; rno:287706; -.
DR UCSC; RGD:1306673; rat.
DR AGR; RGD:1306673; -.
DR CTD; 55175; -.
DR RGD; 1306673; Klhl11.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000159275; -.
DR HOGENOM; CLU_024322_0_0_1; -.
DR OMA; DNYCCFQ; -.
DR OrthoDB; 5472491at2759; -.
DR TreeFam; TF331981; -.
DR Reactome; R-RNO-8951664; Neddylation.
DR Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000016921; Expressed in frontal cortex and 18 other cell types or tissues.
DR CDD; cd18451; BACK_KLHL11; 1.
DR CDD; cd18241; BTB_POZ_KLHL11; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF420; KELCH-LIKE PROTEIN 11; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 709 AA; 80394 MW; 3F123D10FB2DF36A CRC64;
MAAAVAAAAA AAAAAASFQV LEMESMETAV AGSASLAAEV RGSGTVDFVT GAGISTLVDT
GGGDPGPEAE DFECSTHCSE LSWRQNEQRR QGLFCDITLC FGGAGGREFR AHRSVLAAAT
EYFTPLLSGQ FSESRSGRVE MRKWSSEPGP EPDTVEAVIE YMYTGRIRVS TGSVHEVLEL
ADRFLLIRLK EFCGEFLKKK LHLSNCVAIH SLAHMYTLSQ LALKAADMIR RNFYKVIQDE
EFYTLPFHLI RDWLSDLEIT VDSEEVLFET VLKWVQRNAE ERERYFEELF KLLRLSQMKP
TYLTRHVKPE RLVANNEVCV KLVAEAVERH ALRAENIQSG TLQHPTSQVS LLPRYGQNMD
VIMVIGGVSE GGDYLSECVG YFVDEDRWVN LPHIHNHLDG HAVAITESYV YVAGSMEPGF
AKTVERYNPN LNTWEHVCSL MTRKHSFGLT EVKGKLYSIG GHGNFSPGFK DVTVYNPELD
KWHNLESAPK ILRDVKALAV EDRFVYIAAR TPVDRDTEDG LKAVITCYDT ETRQWQDVES
LPLIDNYCFF QMSVVNSNFY QTASCCPKSY SLENEEAVRK IAGQVSDEIL ESLPPEVLSI
EGAAICYYRD DVFIIGGWKN SDDIDKQYRK EAYRYCAERK RWMLLPPMPQ PRCRATACHV
RIPYRYLHGT QRYPMPQNLM WQKDRIRQMQ EIHRHALNMR RVPSSQIEC
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