ID D3ZTX4_RAT Unreviewed; 4481 AA.
AC D3ZTX4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Maltase-glucoamylase {ECO:0000313|Ensembl:ENSRNOP00000016912.8};
GN Name=Mgam {ECO:0000313|Ensembl:ENSRNOP00000016912.8,
GN ECO:0000313|RGD:9369725};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000016912.8, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000016912.8, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016912.8,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000016912.8}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016912.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR AlphaFoldDB; D3ZTX4; -.
DR SMR; D3ZTX4; -.
DR STRING; 10116.ENSRNOP00000016912; -.
DR PaxDb; 10116-ENSRNOP00000016912; -.
DR PeptideAtlas; D3ZTX4; -.
DR Ensembl; ENSRNOT00000016912.8; ENSRNOP00000016912.8; ENSRNOG00000026177.7.
DR AGR; RGD:9369725; -.
DR RGD; 9369725; Mgam.
DR VEuPathDB; HostDB:ENSRNOG00000026177; -.
DR eggNOG; KOG1065; Eukaryota.
DR GeneTree; ENSGT00940000161540; -.
DR HOGENOM; CLU_000631_3_0_1; -.
DR InParanoid; D3ZTX4; -.
DR OMA; YYTARNI; -.
DR BRENDA; 3.2.1.3; 5301.
DR Reactome; R-RNO-189085; Digestion of dietary carbohydrate.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000026177; Expressed in duodenum and 13 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0004558; F:alpha-1,4-glucosidase activity; ISO:RGD.
DR GO; GO:0016160; F:amylase activity; ISO:RGD.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:1901027; P:dextrin catabolic process; ISO:RGD.
DR GO; GO:0000025; P:maltose catabolic process; ISO:RGD.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 5.
DR CDD; cd14752; GH31_N; 5.
DR CDD; cd00111; Trefoil; 5.
DR Gene3D; 3.20.20.80; Glycosidases; 5.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 5.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 10.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 5.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF168; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 3.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 5.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 5.
DR Pfam; PF00088; Trefoil; 5.
DR SMART; SM00018; PD; 5.
DR SUPFAM; SSF51445; (Trans)glycosidases; 5.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 5.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 5.
DR SUPFAM; SSF57492; Trefoil; 1.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 5.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 5.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00779}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D3ZTX4};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 33..78
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 893..943
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 1789..1839
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 2685..2735
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 3579..3629
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DISULFID 57..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 4481 AA; 512474 MW; 4E68C2691CA60405 CRC64;
MVETAHFYMA SSVDAETTGT PDTTLTRTTL NFPECPVLSE AERINCIPDQ SSNKDTCDQR
GCCWDPQGSI SVPCYFSRNH GYKMESDLAN TTAGFTAALK NLASAPVFGN GIENILLTAE
YQTSNRFHFK LTDQTKERYE VPHEHVKPFS GNAASSLNYN VEVFKEPFSI KVTRKSNNRV
LFDSSIGPLL FSDQFLQLST HLPSANVYGL GEHVHQQYRH DMNWKTWPMF ARDTTPNEDG
NNLYGVQTFF LCLEDNSGLS FGVFLMNSNA MEVTLQPTPA ITYRITGGIL DFYVFLGNTP
EQVVQEYLEL IGRPTLPSYW TLGFQLSRYD YGSLDKMKIV VERNRAAQLP YDVQHADIDY
MDQRKDFTYD PVNFKGFPEF VKELHNNGQK LVIILDPAIS NNSLSSNPYG PYDRGSAMKV
WVNSSDGNAL IGKVWPGTTV FPDYTSPNCA VWWKKEIELF HNEVEFDGIW IDMNEVSNFV
DGSVSGCSQN NLNYPPFTPK VLDGNLFSKT LCMDAVQHWG KQYDVHNLYG YSMAIATEEA
VKTVFPDKRS FILTRSTFAG SGKFAAHWLG DNTATWKDLQ WSIPGMLEFN LFGIPMVGAD
ICGFAMNTYE ELCRRWMQLG AFYPFSRNHN GQGYKDQDPA SFGEDSLLLN SSRHYLNIRY
TLLPYLYTLF YRAHSRGDTV ARPLLHEFYE DSNTWDIDRQ FLWGPGLLIT PVLDQGAEKV
KAYVPDATWY DYETGEQLAW RKQSVEMELP EDKIGLHLRG GYIFPTQQPA TTTEASRKNP
LGLIIALDKN KEAKGELFWD DGQTKDTVAK NLYLFTEFSA TQNRLDVTIS SPNYKDPNNL
EFQEIKIFGT QEFRNVKVKQ NGVLLQMSPQ VNYNSNLKVA TITNIHLMLG EAYTVEWDIF
TRDEEKIDCY PDEHGVSEAN CIARGCIWEV SNTPGVPHCY FANELYSVSN IQYNSHGATA
DIFLKASTYS NAFPSTPVNQ LQLKVAYHKD QMLQFKIYDP NRSRYEVPVP LNIPSAPSST
PEGRLYDVFI KENPFGIQIR RKSTGTVIWD SQLLGFTFND MFIRISTRLP STYIYGFGET
EHTTFKIDMN WQTWGMFSRD EPPGYKKNSY GVHPYYMGLE EDGNAHGVLL MNSNAMDVTF
QPMPALTYRT VGGILDFYVF LGPTPEIVTE QYTELIGRPV MVPYWSLGFQ LCRYGYENDT
EIANLYDEMV AKRIPYDVQY SDIDYMERQL DFKLNPKFSG FPDLINRMKD NGMRVILILD
PAISGNETEP YPAFTRGVEN DVFISYPNNG GIVWGKVWPD YPNITVDPSL DWDSQVQQYR
AYVAFPDFFR DSTALWWKNE IKELHSNSQD PAKSLKFDGL WIDMNEPSSF VNGAVPSGCT
DTTLNRPPYM PHLEARDRGL SSKTLCMESE HILPDGSRVR HYDVHSLYGW SQTRPTYEAM
QEVTGERGIV ITRSTFPSSG RWGGHWLGDN TAAWDQLGKS IIGMMDFSLF GISYTGSDIC
GFFQDAEYEM CVRWMQLGAF YPFSRNHNTI GTKRQDPVSW NETFEDISRS VLETRYTLLP
YLYTLMYKAH KEGSTVVRPL LHEFLADRET WNVDKQFLLG PAFLVSPVLE LNARNVTAYF
PKAQWYDYYT GADINSTGEW RTLPAPLEHI NLHVRGGYIL PWQQPALNTN LSRKKPLGLL
IALNENKEAR GELFWDDGQS KDTVAKNIYL FSEFSVTQNR LDVTISSPNY KDPNNLEFQE
IKIFGTQEIR NVKVKQNGVL LQMSPQVNYN SNLKVATITN IHLVLGEAYT VEWDIYSKDV
ERIDCYPDEH GVSEANCTAR GCIWEVSNTP GVPHCYFANE LYSVSNIQYD SHGATADISL
KASPYSNAFP STPVNQLQLK VTYHKDQMLQ FKIYDPNRSR YEVPVPLNIP SAPSSTPEGR
LYDVFIKENP FGIQIRRNST GTVIWDSQLL GFTFNDMFIR ISTRLPSTYI YGFGETEHTT
FKIDMNWQTW GMFSRDEPPG YKKNSYGVHP YYMGLEEDGN AHGVLLMNSN AMDVTFQPMP
ALTYRTTGGI LDFYVFLGPT PEIVTQQYTE LIGRPVMVPY WSLGFQLCRY GYENDTEIAN
LYDEMVAKQI PYDVQYSDID YMERQLDFKL SPKFSGFPDL INRMKDNGMR VILILDPAIS
GNETEPYPAF TRGVENDVFI SYPNNGGIVW GKVWPDYPNI TVDPSLDWDS QVQQYRAYVA
FPDFFRNSTA LWWKNEIKEL HSNSQDPAKS LKFDGLWIDM NEPSSFVNGA VPSGCTDTTL
NRPPYMPHLE ARDRGLSSKT LCMESEHILP DGSRVRHYDV HSLYGWSQTR PTYEAVQEVT
GERGIVITRS TFPSSGRWGG HWLGDNTAAW DQLGKSIIGM MDFSLFGISY TGSDICGFFQ
DAEYEMCVRW MQLGAFYPFS RNHNTIGTKR QDPVSWNKTF EDISRSVLET RYTLLPYLYT
LMYKAHKEGS TVVRPLLHEF LADRETWNVD KQFLLGPAFL VSPVLEPNAR NVTAYFPKAQ
WYDYYTGADI NSTGEWRTLP APLEHINLHV RGGYILPWQQ PALNTNLSRK KPLGLLIALN
ENKEARGELF WDDGQSKDTV AKNIYLFSEF SVTQNRLDVT ISSPNYKDPN NLEFQEIKIF
GTQEILNVKV KQNGVLLQMS PQVNYNSNQK VATITNIHLV LGEAYTVEWD IYSKDMERID
CYPDEHGVSE ANCTARGCIW EVSNIPGVPH CYFANELYSV SNVQYDSHGA TADISLKASP
YSNAFPSTPV NQLQLKVTYH KDQMLQFKIY DPNHSRYEVP VPLNIPRTPS STVDGRLYDV
LIKENPFGIQ IRRKSTGTVI WDSQLLGFTF NDMFIRISTR LPSTYIYGFG ETEHTTFKID
MNWHTWGMFS RDEPPGYKKN SYGVHPYYMG LEEDGNAHGI LLLNSNAMDV TFQPMPALTY
RTTGGILDFY VFLGPTPEIV TQQYTELIGR PVMVPYWSLG FQLCRYGYEN DAEIANLYDE
MVAKQIPYDV QYSDIDYMER QLDFKLNPKF SGFPDLINRM KDNGMRVILI LDPAISGNET
EPYPAFTRGV ENDVFIRYPN NGDIVWGKVW PDYPNIVVNS SLDWDSQVEQ YRAYVAFPDF
FRNSTALWWK KEIEELYRNT QEPAKSLKFD GLWIDMNEPS SFVNGAVPSG CSDTTLNRPP
YMPYLEARDR GLSSKTLCME SEHILPDGSR VRHYDVHSLY GWSQTRPTYE AVQEVTGERG
IVITRSSFPS SGRWGGHWLG DNTAAWDQLG KSIIGMMDFS LFGISYTGSD ICGFFQDAEY
EMCVRWMQLG AFYPFSRNHN TIGTRRQDPV SWNKTFEDIS RSVLETRYTL LPYLYTLMYK
AHTEGSTVVR PLLHEFVSDR ETWSIDKQFL LGPAFLVSPV LEPDARNIRS YFPRALWYDY
YTGENINSTG EWRTLSAPLE HINLHVRGGY ILPWQRPALN THLSRKNPLG LIIALDENKE
ARGELFWDDG QSKDLTTNNI LCKFSVTQNR LDVSTSKSTY TDPDNLTFQE IKIFGTQALY
NVTVKHNGMV NQMSPQVSYD PNMKVALITG IQLLLNESYT VEWDGSIRDG EKMDCYPDQH
GASEANCTAR GCVWEVSNSP GVPFCYFVNE LYSVSNVQYD SHGASANISL KASPYSNAFP
STPVNELQLK VTYHKDEMLQ FKIYDPNHSR YEVPVPLNIP SSPSSTPDNR SYDVFIKENP
FGIEIRRKGT GSVIWDSRLL GFTFNDMFIR ISTRLPSTYI YGFGETEHTT FKIDMNWHTW
GMFSRDEPPG YKKNSYGVHP YYMGLEEDGN AHGILLMNSN AMDVTLQPMP ALTYRTTGGV
LDFFVFLGPT PELVTQQYTE LIGRPVMVPY WSLGFQLCRY GYENDTEIAN LYDDMVAKKI
PYDVQYSDID YMERQLDFKL NPKFSGFPDL INRMKHDGMR VILILDPAIS GNETEPYPAF
TKGVENDVFI RYPNNGDIVW GKVWPDYPNI TVDPSLDWDS QVEQYRAYVA FPDFFRNSTA
LWWKDEIKEL HSNTQDPAKS LKFDGLWIDM NEPSSFVNGA VPSGCSDATL NRPPYMPHLE
ARDRGLSSKT LCMESEHILP DGSRVRHYDV HSLYGWSQTR PTYEAVQEVT GERGIVITRS
TFPSSGRWGG HWLGDNTAAW DQLGKSIIGM MDFSLFGISY TGSDICGFFQ DAEYEMCVRW
MQLGAFYPFS RNHNTIGTRR QDPVSWNKTF EDISRSVLET RYTLLPYLYT LMYKAHTEGS
TVVRPLLHEF VSDRETWNID KQFLLGPAFL VSPVLEPNAR TVAAYFPKAR WYDYYTGVDI
NARGEWKTLQ APLEYINLHV RGGYILPWQE PAMNTQLSRK KSMGLKAALN DEGLAEGWLF
WDDGKSINIT NQYYLARFSV SQNTLQTHEM FNNYITGTVP LYLGYIEIWG LSSPSITSVR
ISGKNLNEEV LADYNTTTQI LRVNVTDKNI SLHAFQSLTW S
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