GenomeNet

Database: UniProt
Entry: D3ZW75_RAT
LinkDB: D3ZW75_RAT
Original site: D3ZW75_RAT 
ID   D3ZW75_RAT              Unreviewed;      1840 AA.
AC   D3ZW75;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 2.
DT   20-DEC-2017, entry version 66.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Scn4a {ECO:0000313|Ensembl:ENSRNOP00000016841,
GN   ECO:0000313|RGD:3636};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000016841, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000016841, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016841,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000016841}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016841};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000016841}.
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DR   EMBL; AABR07072198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC133055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006247621.1; XM_006247559.3.
DR   RefSeq; XP_017452535.1; XM_017597046.1.
DR   UniGene; Rn.9700; -.
DR   PaxDb; D3ZW75; -.
DR   PeptideAtlas; D3ZW75; -.
DR   Ensembl; ENSRNOT00000016841; ENSRNOP00000016841; ENSRNOG00000012134.
DR   GeneID; 25722; -.
DR   CTD; 6329; -.
DR   RGD; 3636; Scn4a.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000012134; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    101    120       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    417    444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    564    588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    600    621       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    641    662       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    683    711       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    770    796       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1025   1043       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1064   1086       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1092   1112       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1141   1167       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1265   1288       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1347   1365       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1377   1395       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1407   1427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1464   1492       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1565   1591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    450       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      574    800       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      810   1019       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1023   1296       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1346   1601       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       25     45       {ECO:0000256|SAM:Coils}.
FT   COILED      452    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1840 AA;  208797 MW;  868954CDF054B8E7 CRC64;
     MASSSLPNLV PPGPHCLRPF TPESLAAIEQ RAVEEEARLQ RNKQMEIEEP ERKPRSDLEA
     GKNLPLIYGD PPPEVIGIPL EDLDPYYSDK KTFIVLNKGK AIFRFSATPA LYLLSPFSIV
     RRVAIKVLIH ALFSMFIMIT ILTNCVFMTM SNPPSWSKHV EYTFTGIYTF ESLIKMLARG
     FCIDDFTFLR DPWNWLDFSV ITMAYVTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV
     GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPMNDT NTTWYGNDTW
     YSNDTWYGND TWYINDTWNS QESWAGNSTF DWEAYINDEG NFYFLEGSND ALLCGNSSDA
     GHCPEGYECI KAGRNPNYGY TSYDTFSWAF LALFRLMTQD YWENLFQLTL RAAGKTYMIF
     FVVIIFLGSF YLINLILAVV AMAYAEQNEA TLAEDQEKEE EFQQMLEKYK KHQEEVEKAK
     AAQALESGEE ADGDPTHNKD CNGSLDASGE KGPPRPSCSA DSAISDAMEE LEEAHQKCPP
     WWYKCAHKVL IWNCCAPWVK FKHIIYLIVM DPFVDLGITI CIVLNTLFMA MEHYPMTEHF
     DNVLSVGNLV FTGIFTAEMV LKLIAMDPYE YFQQGWNIFD SFIVTLSLVE LGLANVQGLS
     VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY
     KECVCKIASD CNLPRWHMND FFHSFLIVFR ILCGEWIETM WDCMEVAGQA MCLTVFLMVM
     VIGNLVVLNL FLALLLSSFS ADSLAASDED GEMNNLQIAI GRIKWGIGFA KTFLLGLLRG
     KILSPKEIIL SLGEPGGAGE NAEESTPEDE KKEPPPEDKE LKDNHILNHV GLTDGPRSSI
     ELDHLNFINN PYLTIHVPIA SEESDLEMPT EEETDAFSEP EDIKKPLQPL YDGNSSVCST
     ADYKPPEEDP EEQAEENPEG EQPEECFTEA CVKRCPCLYV DISQGRGKMW WTLRRACFKI
     VEHNWFETFI VFMILLSSGA LAFEDIYIEQ RRVIRTILEY ADKVFTYIFI LEMLLKWVAY
     GFKVYFTNAW CWLDFLIVDV SIISLVANWL GYSELGPIKS LRTLRALRPL RALSRFEGMR
     VVVNALLGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY YCVNTTTSER FDISVVNNKS
     ECESLMYTGQ VRWMNVKVNY DNVGLGYLSL LQVATFKGWM DIMYAAVDSR EKEEQPDYEV
     NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKFGG KDIFMTEEQK KYYNAMKKLG
     SKKPQKPIPR PQNKIQGMVY DFVTKQVFDI SIMILICLNM VTMMVETDDQ SQLKVDILYN
     INMVFIIIFT GECVLKMFAL RHYYFTIGWN IFDFVVVILS IVGLALSDLI QKYFVSPTLF
     RVIRLARIGR VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYS IFGMSNFAYV
     KKESGIDDMF NFETFGNSII CLFEITTSAG WDGLLNPILN SGPPDCDPTL ENPGTNVRGD
     CGNPSIGICF FCSYIIISFL IVVNMYIAII LENFNVATEE SSEPLSEDDF EMFYETWEKF
     DPDATQFIDY SRLSDFVDTL QEPLKIAKPN KIKLITLDLP MVPGDKIHCL DILFALTKEV
     LGDSGEMDAL KQTMEEKFMA ANPSKVSYEP ITTTLKRKQE EVCAIKIQRA YRRHLLQRSV
     KQASYMYRHS QDGNGDGAPE KEGLLANTMN KMYGHEKEGD GVQSQGEEEK ASTEDAGPTV
     EPKPTSSSDT ALTPSPPPLP PSSSPPQGQT VRPGVKESLV
//
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