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Database: UniProt
Entry: D3ZXT2_RAT
LinkDB: D3ZXT2_RAT
Original site: D3ZXT2_RAT 
ID   D3ZXT2_RAT              Unreviewed;      1231 AA.
AC   D3ZXT2;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   22-NOV-2017, entry version 56.
DE   SubName: Full=Stromal antigen 2 {ECO:0000313|Ensembl:ENSRNOP00000044231};
GN   Name=Stag2 {ECO:0000313|Ensembl:ENSRNOP00000044231,
GN   ECO:0000313|RGD:1562042};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000044231, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000044231, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044231,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000044231}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044231};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000044231}.
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DR   EMBL; AC094527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC111718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001166978.1; NM_001173507.1.
DR   UniGene; Rn.29288; -.
DR   STRING; 10116.ENSRNOP00000044231; -.
DR   iPTMnet; D3ZXT2; -.
DR   PhosphoSitePlus; D3ZXT2; -.
DR   PaxDb; D3ZXT2; -.
DR   PeptideAtlas; D3ZXT2; -.
DR   PRIDE; D3ZXT2; -.
DR   Ensembl; ENSRNOT00000044240; ENSRNOP00000044231; ENSRNOG00000029885.
DR   GeneID; 313304; -.
DR   KEGG; rno:313304; -.
DR   CTD; 10735; -.
DR   RGD; 1562042; Stag2.
DR   eggNOG; KOG2011; Eukaryota.
DR   eggNOG; COG5537; LUCA.
DR   GeneTree; ENSGT00390000014094; -.
DR   InParanoid; D3ZXT2; -.
DR   KO; K06671; -.
DR   Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR   Reactome; R-RNO-2468052; Establishment of Sister Chromatid Cohesion.
DR   Reactome; R-RNO-2470946; Cohesin Loading onto Chromatin.
DR   Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-RNO-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000029885; -.
DR   ExpressionAtlas; D3ZXT2; baseline and differential.
DR   Genevisible; D3ZXT2; RN.
DR   GO; GO:0000785; C:chromatin; ISO:RGD.
DR   GO; GO:0008278; C:cohesin complex; ISO:RGD.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0097431; C:mitotic spindle pole; ISO:RGD.
DR   GO; GO:0016363; C:nuclear matrix; ISO:RGD.
DR   GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR   GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:RGD.
DR   GO; GO:0032876; P:negative regulation of DNA endoreduplication; ISO:RGD.
DR   GO; GO:1901673; P:regulation of mitotic spindle assembly; ISO:RGD.
DR   GO; GO:0007062; P:sister chromatid cohesion; ISO:RGD.
DR   GO; GO:0019827; P:stem cell population maintenance; ISO:RGD.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR020839; SCD.
DR   InterPro; IPR013721; STAG.
DR   Pfam; PF08514; STAG; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   PROSITE; PS51425; SCD; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D3ZXT2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN      293    378       SCD. {ECO:0000259|PROSITE:PS51425}.
FT   COILED      257    287       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1231 AA;  141307 MW;  4750713B24C48B6C CRC64;
     MIAAPEIPTD FNLLQESETH FSSDTDFEDI EGKNQKQGKG KTCKKGKKGP AEKGKSGNGG
     GKPPSGPNRM NGHHQQNGVE NMMLFEVVKM GKSAMQSVVD DWIESYKHDR DIALLDLINF
     FIQCSGCKGV VTAEMFRHMQ NSEIIRKMTE EFDEDSGDYP LTMAGPQWKK FKSSFCEFIG
     VLVRQCQYSI IYDEYMMDTV ISLLTGLSDS QVRAFRHTST LAAMKLMTAL VNVALNLSIN
     MDNTQRQYEA ERNKMIGKRA NERLELLLQK RKELQENQDE IENMMNAIFK GVFVHRYRDA
     IAEIRAICIE EIGIWMKMYS DAFLNDSYLK YVGWTMHDKQ GEVRLKCLTA LQGLYYNKEL
     NSKLELFTSR FKDRIVSMTL DKEYDVAVQA IKLLTLVLQS SEEVLTAEDC ENVYHLVYSA
     HRPVAVAAGE FLYKKLFSRR DPEEDGIMKR RGRQGPNANL VKTLVFFFLE SELHEHAAYL
     VDSMWDCATE LLKDWECMNS LLLEEPLSGE EALTDRQESA LIEIMLCTIR QAAECHPPVG
     RGTGKRVLTA KEKKTQLDDR TRITELFAVA LPQLLAKYSV DAEKVTNLLQ LPQYFDLEIY
     TTGRLEKHLD ALLRQIRNIV EKHTDTDVLE ACSKTYHALC NEEFTIFNRV DISRSQLIDE
     LADKFNRLLE DFLQEGEEPD EDDAYQVLST LKRITAFHNA HDLSKWDLFA CNYKLLKTGI
     ENGDMPEQIV IHALQCAHYV ILWQLAKITE STSTKEDLLR LKKQMRVFCQ ICQHYLTNVN
     TTVKEQAFTI LCDILMIFSH QIMSGGRDML EPLVYTPDSS LQSELLSFIL DHVFIEQDDD
     SNSADGQQED EASKIEALHK RRNLLAAFCK LIVYTVVEMN TAADIFKQYM KYYNDYGDII
     KETMSKTRQI DKIQCAKTLI LSLQQLFNEM IQENGYNFDR SSSTFSGIKE LARRFALTFG
     LDQLKTREAI AMLHKDGIEF AFKEPNPQGE SHPPLNLAFL DILSEFSSKL LRQDKRTVYV
     YLEKFMTFQM SLRREDVWLP LMSYRNSLLA GGDDDTMSVI SGMSSRGSTV RSKKSKPSTG
     KRKVLEGMQL ALPEESSSSD SMWLSREQTL HTPVMMQTPQ LTSTIMREPK RLRPEDSFMS
     VYPMQTEHHQ TPLDYNQRGT SIMEDDEEPI VEDVMMSSEG RIEDLNEGMD FDTMDIDLPP
     SKNRRERTEL KPDFFDPASI MDESVLGVSM F
//
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