ID D4A0J4_RAT Unreviewed; 792 AA.
AC D4A0J4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 3.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=von Willebrand factor A domain containing 2 {ECO:0000313|Ensembl:ENSRNOP00000047286.5};
GN Name=Vwa2 {ECO:0000313|Ensembl:ENSRNOP00000047286.5,
GN ECO:0000313|RGD:1562000}; Synonyms=Vwa2-ps1 {ECO:0000313|RGD:1562000};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000047286.5, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000047286.5, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047286.5,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000047286.5}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047286.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_003749194.3; XM_003749146.4.
DR RefSeq; XP_003753476.3; XM_003753428.4.
DR AlphaFoldDB; D4A0J4; -.
DR SMR; D4A0J4; -.
DR STRING; 10116.ENSRNOP00000047286; -.
DR PaxDb; 10116-ENSRNOP00000047286; -.
DR PeptideAtlas; D4A0J4; -.
DR Ensembl; ENSRNOT00000051834.6; ENSRNOP00000047286.5; ENSRNOG00000025581.7.
DR GeneID; 307988; -.
DR KEGG; rno:307988; -.
DR AGR; RGD:1562000; -.
DR CTD; 340706; -.
DR RGD; 1562000; Vwa2.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000159040; -.
DR HOGENOM; CLU_008905_7_3_1; -.
DR InParanoid; D4A0J4; -.
DR OMA; MWCSAAM; -.
DR OrthoDB; 5299728at2759; -.
DR TreeFam; TF318242; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000025581; Expressed in kidney and 12 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0007161; P:calcium-independent cell-matrix adhesion; ISO:RGD.
DR GO; GO:0046626; P:regulation of insulin receptor signaling pathway; ISO:RGD.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd01472; vWA_collagen; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF20; COLLAGEN ALPHA-1(XXI) CHAIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00092; VWA; 3.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50234; VWFA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..792
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003053390"
FT DOMAIN 60..234
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 304..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..525
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 539..713
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 720..756
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 770..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 746..755
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 792 AA; 86538 MW; EC4CB9BD596BD353 CRC64;
MRRRTRSNNM PPYLFLPAIY TLLFSRVSLS SSLQEVHVSR ETTGKIAVAS KLIWCSAAVD
ILFLLDGSHS IGKGSFERSK RFATALCDAL DISPGRVRVG ALQFGSTPHL EFPLDAFSTR
QEVKEIIKKL VFKGGRTETG LALKHLLRGL PGGRNGSVPQ ILIIITDGKS QGHVALPAKQ
LKERGIVVFA VGVRFPRWDE LLTLASEPKE QHVLLAEQVE DATNGLLSTL SSSLLCTTAD
PDCRVEAYPC ERRTLETMRE LASNALCWRG SRQADTVLAV PCPFYSWKRV FQTHPANCYR
TICPGPCDSQ PCQNGGTCIP EGVDRYHCLC PLAFGGEVNC APKLSLECRI DVLFLLDSSA
GTTPEGFRQA KAFVKRFVQA VLSEDSRARV GVASYSRDLM VAVPVGEYQH VPDLVRILDS
IPFSGGPTLT GSALLQVTEH GFGSASRTGQ DRPRRVVVLL TESHAQDEVA GPADHARARE
LLLLGMGNEL MRAELERITG SRKHVIIHTD PRDMFSQIPE LQRRLCSQPR PGCQAQSLDL
VFLLDASASV GGENFAQMQS FIRKCTLRFD VNPDVTQVGL VVYGNQVQTA FGLDTHPTRA
SVLRAMSQAP YLGGVGSAGT ALLHIEDKVM TVQRGARPGV PKAVVMLTGG SGAEDAAVPA
QKLRDNGISV LVMSVGAVLK EAVRRLAGPR DYLIHVAAYT DLRYHQDTLI EWLCREAKRP
VSLCKPSPCM NEGTCILKNG SYRCECWGGW EGPHCENRVL RGDAPMAHSF RREPTGRQQP
TPSQQAPKHV GV
//
