ID   D4AMB6_ARTBC            Unreviewed;       821 AA.
AC   D4AMB6;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Rad2-like endonuclease, putative {ECO:0000313|EMBL:EFE35327.1};
GN   ORFNames=ARB_05369 {ECO:0000313|EMBL:EFE35327.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE35327.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE35327.1}.
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DR   EMBL; ABSU01000003; EFE35327.1; -; Genomic_DNA.
DR   RefSeq; XP_003015972.1; XM_003015926.1.
DR   AlphaFoldDB; D4AMB6; -.
DR   STRING; 663331.D4AMB6; -.
DR   GeneID; 9523807; -.
DR   KEGG; abe:ARB_05369; -.
DR   eggNOG; KOG2519; Eukaryota.
DR   HOGENOM; CLU_007575_0_1_1; -.
DR   OMA; IWQFQNQ; -.
DR   OrthoDB; 1779469at2759; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR   CDD; cd09906; H3TH_YEN1; 1.
DR   CDD; cd09870; PIN_YEN1; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR041177; GEN1_C.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   InterPro; IPR037316; Yen1_H3TH.
DR   PANTHER; PTHR11081:SF71; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   Pfam; PF18380; GEN1_C; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00484; XPGI; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000313|EMBL:EFE35327.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866}.
FT   DOMAIN          162..240
FT                   /note="XPG-I"
FT                   /evidence="ECO:0000259|SMART:SM00484"
FT   REGION          453..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          672..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  90638 MW;  8010A3D18CD93783 CRC64;
     MTSSARVFHA AALENWAVTN LIEEVEAPRD ESLFLVRRQD ILCLPRPSSQ LPQPKGNNAL
     GTIHRDPPPF DRNRNVHVCV LTHEWGFLAV DISIWLFQVQ AAQGGTNPAL RTLFFRLTRL
     ISLPIQPIFV FDGPHRPDYK RGRLVSKNAA AAQIELSRKL IELFSYPCHM APGEAEAECA
     KLQQAGVVDA VMSNDVDALM FGSKVTLLNY SKGSAKQSGA ATHVDLYNTE AEDGDSKVTL
     DTRGMVLVAL LSGGDYSPAG VALCGPKLAV EIARAGFGED LLEITQDLLS GRSTKKAEEA
     LCEWRERLQY ELQSNESGYF KTKHKAVKIP ADFPNLAALR SCVDPVTSSL KEMDALRRSD
     IWGRRVDVDR LRAFVGKYLG WKNAIGAKNL IRKLAPSLLS YNLFYSSLGT PKDKLPLKIL
     GYKSADSFDA LPVLKLEYVP LQIVNVDLDQ ETTTASPQEE EVMNIDSSDN DDTPKESHAM
     VRKSTLAEYD PSASQKAWLF ETIVRRGIPD TVDDWFAECK KKEAAKKRPV KKSEARKKKP
     KVVDPGMKAG SILRYGTITK GPVIQRNATS SLAKESPPSS NHSLPYSDIA GTQKPPISSG
     KSTDLPASSE FIDLTFSDPL DDPVGSDHTQ DRKDLALSHV HISEKMLPGS TRPDIVCAPS
     QKRKIPKCKE RIPAPSVQPN EPKLPKEKKA ITKSPSPLPS YSTTQEFPSL NQLSIELENI
     YNMNPPGDTR TRHQKTDRHI LYRDNGPPAP EGIMDAFKPE MIFCEHRPPA LHVKIDNGFW
     TQVQGATTDC PCLLSSEKNS SLNCLSGRPI CLGYVSIVDL T
//