ID   D4ARW8_ARTBC            Unreviewed;       512 AA.
AC   D4ARW8;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Vacuolar aspartyl aminopeptidase Lap4 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ARB_06983 {ECO:0000313|EMBL:EFE34032.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE34032.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290, ECO:0000256|RuleBase:RU004386}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE34032.1}.
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DR   EMBL; ABSU01000007; EFE34032.1; -; Genomic_DNA.
DR   RefSeq; XP_003014421.1; XM_003014375.1.
DR   AlphaFoldDB; D4ARW8; -.
DR   STRING; 663331.D4ARW8; -.
DR   GeneID; 9520473; -.
DR   KEGG; abe:ARB_06983; -.
DR   eggNOG; KOG2596; Eukaryota.
DR   HOGENOM; CLU_019532_3_0_1; -.
DR   OMA; LLDTHYY; -.
DR   OrthoDB; 1156at2759; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05658; M18_DAP; 1.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF4; VACUOLAR AMINOPEPTIDASE 1; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU004386};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   512 AA;  56000 MW;  C274124677CF48FC CRC64;
     MTKKVPSIAS FGSSSEYLSQ SQASLQYRPR ALDESIHHEH TEFNPGAYTR PFCEFMTKNP
     TIFHAVNAFA EKLEAKGYIK LTEREPWCLA RGKKYYVTRN DSAIISFAIG KHYTPGNGMA
     IVGGHVDALC TKLKPLPTVP NKAGYVQLGV APYAGAMNST WWDRDLGIGG RVLVRDPKTN
     KVERRLVKLD WPIARIPTLA PHFGSAAVGP FNKETQMTPI IGVDNSDLFK GPELSTKDSY
     GGDLGTDNFT STQPKGLVNA IAKQLDVDHS TIVNWELELF DIQPAQVGGL NKDLIFAGRI
     DDKLCCYSAH EAVLASPDHM SSGIIKMVGM FDDEEIGSLL RGGANSNFMS SVMERITQSL
     CRESYGPNIL SQTVANSFFV SSDVTHAVNP NFLNAYLENH SPRLNYGVAV STDPNGHMTT
     EGVSTALFQR LAVKGGCKLQ VFQIRNDSRS GGTIGPMTSA RIGMRAIDVG IPQLSMHSIR
     ATTGSLDPGL GVQMFKAFFD HFEEVDKEFA DF
//