ID D4B4G3_ARTBC Unreviewed; 581 AA.
AC D4B4G3;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 28-JUN-2023, entry version 59.
DE RecName: Full=Vacuolar protein 8 {ECO:0000256|ARBA:ARBA00026209, ECO:0000256|RuleBase:RU369097};
GN ORFNames=ARB_03352 {ECO:0000313|EMBL:EFE30011.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE30011.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000256|ARBA:ARBA00024821,
CC ECO:0000256|RuleBase:RU369097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462, ECO:0000256|RuleBase:RU369097}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE30011.1}.
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DR EMBL; ABSU01000034; EFE30011.1; -; Genomic_DNA.
DR RefSeq; XP_003010651.1; XM_003010605.1.
DR AlphaFoldDB; D4B4G3; -.
DR STRING; 663331.D4B4G3; -.
DR GeneID; 9524763; -.
DR KEGG; abe:ARB_03352; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR OMA; VWDKPDG; -.
DR OrthoDB; 2721872at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR GO; GO:0000011; P:vacuole inheritance; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR Pfam; PF00514; Arm; 7.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 6.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|RuleBase:RU369097, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554, ECO:0000256|RuleBase:RU369097}.
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 152..194
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 193..235
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 234..276
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 277..319
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 318..360
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 359..402
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 581 AA; 63542 MW; 2545E01B01E952A5 CRC64;
MGNACLSCLT GRSRDSLYEP IIADSEREAV ADLLQYLENR NETDFFTGEP LRALSTLVYS
DNVDLQRSAS LTFAEITERD VREVDRDTLE PILFLLESPD IEVQRAASAA LVCLFFFSFF
FSLVFFVSST ETLEADQILL LAENKVSIVM LGGLAPLIRQ MMSTNVEVQC NAVGCITNLA
THEENKAKIA GSGALGPLTR LARSKDMRVQ RNATGALLNM THSDENRQQL VLAGAIPILV
QLLTSPDVDV QYYCTTALSN IAVDALNRKK LAQTESRLVQ SLVQLMDSST PKVQCQAALA
LRNLASDDKY QLEIVRARGL PPLLRLLQSS YLPLILSAVA CIRNISIHPN NESPIIDAGF
LKPLVDLLGS IDNEEIQCHA ISTLRNLAAS SDRNKELVLE AGAVQKCKEL VLQVPLTVQS
EMTAAIAVLA LSDDLKGRLL KLGVFEVLIP LTASESIEVQ GNSAAALGNL SSKVGDYSIF
VRDWTEPNGG LHGYLNRFLA SGDPTFQHIA IWTLLQLIES EDKRLIGFIT RSEDIIQLVR
AIANKNLESD DEGEDGEEGT AEVIALAQRS LELLGFDSKH S
//
