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Database: UniProt
Entry: D4D6W9_TRIVH
LinkDB: D4D6W9_TRIVH
Original site: D4D6W9_TRIVH 
ID   D4D6W9_TRIVH            Unreviewed;       677 AA.
AC   D4D6W9;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=ATP-dependent RNA helicase DED1 {ECO:0000256|ARBA:ARBA00024397};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE   AltName: Full=ATP-dependent RNA helicase ded1 {ECO:0000256|ARBA:ARBA00024405};
GN   ORFNames=TRV_02846 {ECO:0000313|EMBL:EFE42407.1};
OS   Trichophyton verrucosum (strain HKI 0517).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663202 {ECO:0000313|EMBL:EFE42407.1, ECO:0000313|Proteomes:UP000008383};
RN   [1] {ECO:0000313|Proteomes:UP000008383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HKI 0517 {ECO:0000313|Proteomes:UP000008383};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in translation initiation.
CC       Remodels RNA in response to ADP and ATP concentrations by facilitating
CC       disruption, but also formation of RNA duplexes.
CC       {ECO:0000256|ARBA:ARBA00025161}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1
CC       subfamily. {ECO:0000256|ARBA:ARBA00024358}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE42407.1}.
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DR   EMBL; ACYE01000147; EFE42407.1; -; Genomic_DNA.
DR   RefSeq; XP_003023025.1; XM_003022979.1.
DR   AlphaFoldDB; D4D6W9; -.
DR   GeneID; 9583045; -.
DR   KEGG; tve:TRV_02846; -.
DR   HOGENOM; CLU_003041_16_3_1; -.
DR   OrthoDB; 5480645at2759; -.
DR   Proteomes; UP000008383; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd17967; DEADc_DDX3_DDX4; 1.
DR   CDD; cd18787; SF2_C_DEAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR044763; Ded1/Dbp1_DEADc.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR   PANTHER; PTHR47958:SF32; RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000492};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022540}.
FT   DOMAIN          198..226
FT                   /note="DEAD-box RNA helicase Q"
FT                   /evidence="ECO:0000259|PROSITE:PS51195"
FT   DOMAIN          229..422
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          433..593
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          595..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           198..226
FT                   /note="Q motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT   COMPBIAS        8..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  72107 MW;  F5D3A79AE5E725B7 CRC64;
     MADNLKIGNL SLNDSQHAPN QTGRSAYIPP HLRGQARQAA AAESAAGPTV DGPDGPAPGQ
     NGRPAGMNAS AWAPGAPNNA PGWGAGDYGP RGGPAVNGNS GWGQPAGSRR TFDPHAYGHP
     GHQGQQGGNY GGGGAARGSG DGQWRDGKHI PGPSNARLER ELFGIPNDPS KQHTGINFAN
     YDDIPVEASG QNVPEPVSTF TNPPLDDHLI SNIKLASYKV PTPVQKYSIP IVMGGRDLMA
     CAQTGSGKTG GFLFPILSQA FQNGPSPAPT QQGGQFSYGR QRKAYPTSLI LAPTRELVSQ
     IYDEARKFAY RSWVRPCVVY GGADIGSQLR QIERGCDLLV ATPGRLVDLI ERGRISLCNI
     KYLVLDEADR MLDMGFEPQI RRIVEGEDMP PVAGRQTLMF SATFPRDIQM LARDFLKDYV
     FLSVGRVGST SENITQKVEY VEDNDKRSVL LDILHTHGAG LTLIFVETKR MADSLSEFLI
     NQHFPATAIH GDRTQRERER ALEYFRNGRC PILVATAVAA RGLDIPNVTH VVNYDLPTDI
     DDYVHRIGRT GRAGNTGIST AFFNRGNRGV VRDLIELLKE AHQEVPSFLE NIAREGSGYG
     GRGGRGRGRG SAGANRDMRR MGGGMGGPPS YGGGGNYAAP QSYGGGGGNY GGGPYGGGYG
     GGGYGNPSGP TGPSSWW
//
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