ID D4DA32_TRIVH Unreviewed; 1068 AA.
AC D4DA32;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB {ECO:0000256|ARBA:ARBA00015819};
DE AltName: Full=Sulfur controller B {ECO:0000256|ARBA:ARBA00032113};
DE AltName: Full=Sulfur metabolite repression control protein B {ECO:0000256|ARBA:ARBA00030034};
GN ORFNames=TRV_03976 {ECO:0000313|EMBL:EFE41269.1};
OS Trichophyton verrucosum (strain HKI 0517).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663202 {ECO:0000313|EMBL:EFE41269.1, ECO:0000313|Proteomes:UP000008383};
RN [1] {ECO:0000313|Proteomes:UP000008383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HKI 0517 {ECO:0000313|Proteomes:UP000008383};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC involved in the regulation of sulfur metabolite repression, probably by
CC mediating the inactivation or degradation of the metR transcription
CC factor. {ECO:0000256|ARBA:ARBA00002730}.
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC {ECO:0000256|ARBA:ARBA00011725}.
CC -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC {ECO:0000256|ARBA:ARBA00007968}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE41269.1}.
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DR EMBL; ACYE01000204; EFE41269.1; -; Genomic_DNA.
DR RefSeq; XP_003021887.1; XM_003021841.1.
DR AlphaFoldDB; D4DA32; -.
DR GeneID; 9578770; -.
DR KEGG; tve:TRV_03976; -.
DR HOGENOM; CLU_000288_103_3_1; -.
DR OrthoDB; 587035at2759; -.
DR Proteomes; UP000008383; Unassembled WGS sequence.
DR CDD; cd22147; F-box_SpPof1-like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19849; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 477..524
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 738..777
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 808..827
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 854..893
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 894..935
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 936..975
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 976..1014
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 117089 MW; 7E5E2342B79A932E CRC64;
MSPLSGKSTR KPANSPPNDA ESALPEPTVT SSFNAASEED TAQKSDDCIP SSGTVGQFSF
APATQTTVVT TTTTTTTKFP PFVMRPPRFS GQLDPKVYPL ASMPTPAPLR DIRFVLNGKS
VIFHEADDVP GILSKFNEQQ ESLKTSGAIR SMSRDAPESS KSDASNSNLL IRSRPPRSSD
TRRPPSPTSN PTAKPTPATI HNSSEEQLQQ TGSEHTVLSR RYDLPQRELG LATPETENTS
FLHCNKGKRG QRTRSMLGKQ YHEEPPSVSG IASPIAPSDK DSNGDSCGDG LEKSPLLEKQ
SSTAPTQAAG RRGNTQLDNG SIDSNLRKSM KMKLQVKSRR NKQGLLGLEP SNSQNMCLPS
PSLSPIALMN AQRLGEASDS TDDGGADSSL DELPKPSNKG IRTKKAKKIM DYSKKIASRG
CMPLSPNSSV LDMPNMLSSF EAIPDELKSY MMYQFLRRCP KSTLHLVANV VNPALKCDFL
SNLPLELGLN IVKYLDVKSM CRASQVCRKW RHIINSDEKT WKAHFVADGF VLPAGELQQA
IEQGWGWQFS MSPSDGEKDL RNQSFRSSDS ECSSSSAWHP DVTDSKIATL PTPFSPSPRR
LKRKATAHLS GRRAAKRAET VLPSPSEDKA TPWLQEQLTA SENPFIAANA AAMAVPYPDF
GLPSLKSLHL YKTLYQRHYS IKHNWMREDA KPLHLAFRAH DRHVVTCLQF DTDKILTGSD
DTNINVYNTK TGALQSTLQG HEGGVWALEY YGNTLVSGST DRSVRVWDIE SAKCTQIFHG
HTSTVRCLQI LLPAEVGTLP DGTPEMMPKE PLIITGSRDS TLRVWTLPKP SDPTYFQAGP
AQDDGTCPYF VRVMVGHTHS VRAIAAHGDT LVSGSYDCTV RVWKISTGEA VHCLQGHSFK
VYSVVLDHKR NRCISGSMDH MVKIWSLDTG AVLYNLEGHT SLVGLLDLNA GRLVSAAADY
TLRIWDPENG QCKNTLTAHT NAITCFQHDS QKVISGSDRT LKMWNVKTGE CLKDLLTDLS
GVWQVLDFGA YRDGTPAHKL GQRIVVDENG EEISDDAKPP VEEEVSDS
//
