ID D4DAX1_TRIVH Unreviewed; 360 AA.
AC D4DAX1;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase family protein, putative {ECO:0000313|EMBL:EFE40978.1};
GN ORFNames=TRV_04269 {ECO:0000313|EMBL:EFE40978.1};
OS Trichophyton verrucosum (strain HKI 0517).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663202 {ECO:0000313|EMBL:EFE40978.1, ECO:0000313|Proteomes:UP000008383};
RN [1] {ECO:0000313|Proteomes:UP000008383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HKI 0517 {ECO:0000313|Proteomes:UP000008383};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE40978.1}.
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DR EMBL; ACYE01000217; EFE40978.1; -; Genomic_DNA.
DR RefSeq; XP_003021596.1; XM_003021550.1.
DR AlphaFoldDB; D4DAX1; -.
DR GeneID; 9578557; -.
DR KEGG; tve:TRV_04269; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000008383; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EFE40978.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..276
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 360 AA; 40171 MW; 4C872BF595E13A0E CRC64;
MDPVLVIGGC GGLGHTIVKQ LLEKGDASDV TVFDIETKRN IVEGAKYIKG SIGSKEDIQR
ALQQVKPRTI FHSASPLLMQ QKNTQRLYEK INVEGNRYLL DAIQEVQSVR ALVYTSSSSV
IHNGFSDIIE ATEDLPRVFY PEQPEFYSHT KALAEEMIVA ANRTNGLLTV ILRGTTLFGE
GDTLTIPHMV NNAKTGRNKV RVGDGKNLFD FTYLGNCAYA HILAAKALVE IDPAAPPPPA
DKRVDGEVFV VTNDEHISFW EFVYAVGDAA GYPTKREEIW QVPAALFFAV VVAVEWTVWA
ISLGRRESRL NRKMVRYLSM TRTFDISKIK SRLGYRPLVG MQEAIKRSVD AYMREQSAQS
//
